Results 241 to 250 of about 132,120 (348)

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis. [PDF]

Adv Sci (Weinh)
Bai C, Zhang M, Liu L, Tao L, Xu C, Chai H, Shi X, Wang Y, Zhang X, Chen Q, Liu D, Bai J, She C, Zhou X, Cao C, Shan H.   +15 more
europepmc   +1 more source

Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway

, 2020
Chongwen Ma, Bin Geng, Xiaohui Zhang, Rui Li, Xinxin Yang, Yayi Xia   +5 more
openalex   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases. [PDF]

Cell Discov
Zhu S, Yan MQ, Masson A, Chen W, Li YP.
europepmc   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Nutrients and Metabolites as Signalling Molecules in Osteoclasts. [PDF]

Curr Osteoporos Rep
Chandrasekaran K, Hu S, Farstad-O'Halloran K, Iyer KS, Jiang H, Pavlos N, Chen K.   +6 more
europepmc   +1 more source

Osteoclasts [PDF]

, 2008
openaire   +1 more source

miRNA Profiling of Cholesteatoma‐Derived Exosomes Reveals Exosomal miR‐223‐3p and miR‐142‐5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Acquired cholesteatoma is an abnormal and invasive growth of keratinized squamous epithelial cells in the middle ear. The study aims to explore the role of exosomal miRNAs in the pathogenesis of acquired cholesteatoma and their potential in clinical application.
Qi Tang, Meng‐Yao Xie, Shu Wang, Zhi‐Yuan Wu, Zhi‐Jin Han, Chen Li, Shu‐Yi Wang, Yuan Cao, Yu‐Run Chen, Bin Wang, Ying‐Ying Shang, Xiao‐Wu Huang, Hua Yang   +12 more
wiley   +1 more source

Alcohol consumption exacerbates high-fat diet-mediated disruptions in myelopoiesis and osteoclastogenesis in mouse models of metabolic dysfunction-associated liver diseases. [PDF]

Front Endocrinol (Lausanne)
Hemati H, Blanton MB, Rutt L, Keiran N, Geron R, Lima F, McCullough RL, Messaoudi I.   +7 more
europepmc   +1 more source

Biochemical bone biomarkers in plasma cell dyscrasias

British Journal of Haematology, EarlyView.
Visual abstract depicting that bone turnover markers reflect dynamic alterations in bone remodelling across the spectrum of plasma cell dyscrasias but remain limited by assay variability, biological confounding and incomplete integration with imaging and risk stratification.
Guido Nador, Rohit Vijjhalwar, Muhammad Kassim Javaid, Claire M. Edwards, Karthik Ramasamy   +4 more
wiley   +1 more source