Results 241 to 250 of about 134,929 (355)

Periodontitis‐Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine‐Mediated Acidosis Adaptation

Cell Proliferation, EarlyView.
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu, Zihan Cai, Hualing Sun, Haikun Yu, Bicheng Zhang, Chi Zhang, Yi Fan, Xiaoxuan Zhu, Yueqi Ni, Yu Cui, Kaixin Wang, Zhe Li, Xinyi Zhou, Qing He, Yanru Wu, Yufeng Zhang   +15 more
wiley   +1 more source

From force to resorption: mechanotransduction, osteoclasts, prevention. [PDF]

Prog Orthod
Shen F, Xia X, Han Y, Yu M, Ding W.
europepmc   +1 more source

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts.

Journal of Clinical Investigation, 2000
K. Mchugh, K. Hodivala-Dilke, M. Zheng, N. Namba, Jonathan D. Lam, D. Novack, Xunqiang Feng, F. Ross, R. Hynes, S. Teitelbaum   +9 more
semanticscholar   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Spectrum and functions of ion channels and transporters in osteoclasts. [PDF]

Bone Res
Chen H, Zhang Y, Zhu Y, Xiao X, Huang S, Duan X.   +5 more
europepmc   +1 more source

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert, Phillipp Brockmeyer, Philipp Kauffmann, Jan Wiegel, Florian Lautenbacher, Nicolai Miosge, Boris Schminke   +6 more
wiley   +1 more source

Integration of Bone Remodeling and Damage Accumulation: A Preliminary Computational Framework for Physiological and Pathological Responses. [PDF]

Acta Biotheor
Garzón-Alvarado DA, Duque-Daza CA, Linero DL, Nedjar B, May A, Casas EBL, Ramtani S.   +6 more
europepmc   +1 more source

Intramuscular myxoma with chondroid features: two cases expanding the morphological spectrum

Histopathology, EarlyView.
Background Intramuscular myxoma is a benign mesenchymal tumour typically composed of bland spindle to stellate cells in abundant myxoid stroma and usually characterized by GNAS mutations. Chondroid matrix has not been previously reported in intramuscular myxoma.
Bethany Batson, Azfar Neyaz, Lucas Da Gama Lobo, Rana Naous, Stella J Lee, Ivy John   +5 more
wiley   +1 more source

Targeting Osteoclastogenesis: Sabutoclax reduces tumor-associated osteolysis and tumor burden within the bone microenvironment. [PDF]

Am J Cancer Res
Liao L, Xu Y, Liao J, Liu X, Cheng J, Zhao J.   +5 more
europepmc   +1 more source

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

Proceedings of the National Academy of Sciences of the United States of America, 2008
Larry Pederson, M. Ruan, J. Westendorf, S. Khosla, M. Oursler   +4 more
semanticscholar   +1 more source