Results 161 to 170 of about 27,584 (206)
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Zeitschrift fur Orthopadie und Unfallchirurgie, 2019
For a long time, osteocytes were regarded as passive bystanders of bone metabolism. Bone remodeling was considered to be an interplay between bone forming osteoblasts and bone degrading osteoclasts. However, the dogma of osteocytes as bystanders within the bone has changed fundamentally since the turn of the millenium.
Markus, Rupp +5 more
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For a long time, osteocytes were regarded as passive bystanders of bone metabolism. Bone remodeling was considered to be an interplay between bone forming osteoblasts and bone degrading osteoclasts. However, the dogma of osteocytes as bystanders within the bone has changed fundamentally since the turn of the millenium.
Markus, Rupp +5 more
openaire +2 more sources
Current Osteoporosis Reports, 2021
While the function of osteocytes under physiologic conditions is well defined, their role and involvement in cancer disease remains relatively unexplored, especially in a context of non-bone metastatic cancer. This review will focus on describing the more advanced knowledge regarding the interactions between osteocytes and cancer.We will discuss the ...
Fabrizio Pin +3 more
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While the function of osteocytes under physiologic conditions is well defined, their role and involvement in cancer disease remains relatively unexplored, especially in a context of non-bone metastatic cancer. This review will focus on describing the more advanced knowledge regarding the interactions between osteocytes and cancer.We will discuss the ...
Fabrizio Pin +3 more
openaire +2 more sources
The International Journal of Biochemistry & Cell Biology, 2004
Osteocytes are the most numerous cells in mature bone and have the potential to live as long as the organism itself. However, study and subsequent understanding of osteocyte biology has been thwarted by the remote location of the cell in the mineralized matrix.
Melissa L, Knothe Tate +3 more
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Osteocytes are the most numerous cells in mature bone and have the potential to live as long as the organism itself. However, study and subsequent understanding of osteocyte biology has been thwarted by the remote location of the cell in the mineralized matrix.
Melissa L, Knothe Tate +3 more
openaire +2 more sources
Bone, 2021
MicroRNAs, identified in the early 1990s, are believed to regulate approximately 30% of the human genome. The role of microRNA in bone cells was first reported in 2007 in a manuscript showing that microRNA-223 is essential for osteoclast differentiation in vitro, and a few studies reported a role of microRNAs in osteoblasts the same year.
Plotkin, Lilian I., Wallace, Joseph M.
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MicroRNAs, identified in the early 1990s, are believed to regulate approximately 30% of the human genome. The role of microRNA in bone cells was first reported in 2007 in a manuscript showing that microRNA-223 is essential for osteoclast differentiation in vitro, and a few studies reported a role of microRNAs in osteoblasts the same year.
Plotkin, Lilian I., Wallace, Joseph M.
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Osteocytes and Diabetes: Altered Function of Diabetic Osteocytes
Current Osteoporosis Reports, 2020Diabetes mellitus is a prevalent chronic disease affecting millions of people in the world. Bone fragility is a complication found in diabetic patients. Although osteoblasts and osteoclasts are directly affected by diabetes, herein we focus on how the diabetic state-based on hyperglycemia and accumulation of advanced glycation end products among other ...
Arancha R. Gortázar, Juan A. Ardura
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Archives of Biochemistry and Biophysics, 2008
The osteocyte resides in the lacuna/canalicular system in bone and has been hypothesized to orchestrate local bone remodeling. Certainly the identification of the osteocyte as the source of Sclerostin, a molecule that regulates osteoblast function, has supported this possibility.
exaly +3 more sources
The osteocyte resides in the lacuna/canalicular system in bone and has been hypothesized to orchestrate local bone remodeling. Certainly the identification of the osteocyte as the source of Sclerostin, a molecule that regulates osteoblast function, has supported this possibility.
exaly +3 more sources
Isolation of fossil osteocytes
Journal of the Royal Microscopical Society, 1965During routine maceration of shales for the extraction of fossil spores, a number of unusual structures appeared which were eventually identified as osteocytes from scales belonging to a palaeoniscid, a primitive bony fish. No vertebrate tissues had been expected, since the technique employed destroys virtually all substances with the exception of ...
R, NEVES, L B, TARLO
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Current Osteoporosis Reports, 2003
The osteocyte is the most abundant cell type of bone. There are approximately 10 times as many osteocytes as osteoblasts in adult human bone, and the number of osteoclasts is only a fraction of the number of osteoblasts. Our current knowledge of the role of osteocytes in bone metabolism is far behind our insight into the properties and functions of the
Klein Nulend, J. +2 more
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The osteocyte is the most abundant cell type of bone. There are approximately 10 times as many osteocytes as osteoblasts in adult human bone, and the number of osteoclasts is only a fraction of the number of osteoblasts. Our current knowledge of the role of osteocytes in bone metabolism is far behind our insight into the properties and functions of the
Klein Nulend, J. +2 more
openaire +3 more sources
The Journal of Bone & Joint Surgery, 1960
Counts of the percentage of empty osteocyte lacunae were done on fresh, undecalcified bone sections of specimens from forty-five human subjects ranging in age from new-born infancy to eighty-four years. The average figures from arbitrary age groups suggest that an increasing percentage of bone dies with increasing age.
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Counts of the percentage of empty osteocyte lacunae were done on fresh, undecalcified bone sections of specimens from forty-five human subjects ranging in age from new-born infancy to eighty-four years. The average figures from arbitrary age groups suggest that an increasing percentage of bone dies with increasing age.
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The osteocyte as a signaling cell
Physiological Reviews, 2022Jesús Delgado, Teresita M Bellido
exaly