Results 121 to 130 of about 198,118 (384)

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Macroscopic Anisotropic Bone Material Properties in Children with Severe \u3cem\u3eOsteogenesis imperfecta\u3c/em\u3e [PDF]

, 2017
Children with severe osteogenesis imperfecta(OI) typically experience numerous fractures and progressive skeletal deformities over their lifetime. Recent studies proposed finite element models to assess fracture risk and guide clinicians in determining ...
Albert, Carolyne, Harris, Gerald, Jameson, John, Smith, Peter, Tarima, Sergey   +4 more
core   +1 more source

Exosomal miR-186 derived from BMSCs promote osteogenesis through hippo signaling pathway in postmenopausal osteoporosis

Journal of Orthopaedic Surgery and Research, 2020
Background Postmenopausal osteoporosis (PMO) that results from estrogen withdrawal is the most common primary osteoporosis among older women. However, little is known about the mechanism of PMO, and effective treatment of PMO is limited.
Lu Li, Xin Zhou, Jun-tao Zhang, Aifeng Liu, Chao Zhang, Jingpei Han, Xiao-qing Zhang, Si Wu, Xiao-yu Zhang, Fu-quan Lv   +9 more
semanticscholar   +1 more source

Differential Phase Contrast Imaging to Predict MSC Immune Function

Advanced Healthcare Materials, EarlyView.
This work employs quantitative differential phase contrast (qDPC) imaging technique to non‐invasively extract morphological features from live Mesenchymal Stromal Cells (MSCs) for single cell prediction on cell immunomodulatory capacity. This work establishes a foundation for scalable, non‐destructive monitoring of MSCs immunomodulatory capacity ...
Kejie Rui, Priyanka Priyadarshani, Adrian Ross Liversage, Carlos Munoz, Steven Stice, Luke J. Mortensen   +5 more
wiley   +1 more source

Therapeutic Implants: Mechanobiologic Enhancement of Osteogenic, Angiogenic, and Myogenic Responses in Human Mesenchymal Stem Cells on 3D‐Printed Titanium Truss

Advanced Healthcare Materials, EarlyView.
This study investigates a synergistic effect between 3D‐printed surface features and mechanical micro‐strain in enhancing the osteogenic, angiogenic, and myogenic responses of human mesenchymal stem cells (hMSCs). Load‐induced mechanotransduction, facilitated by the implant's architectural design, significantly amplifies hMSC differentiation.
Se‐Hwan Lee, Ali Kiapour, Brendan D. Stoeckl, Ellen Y. Zhang, Matthew R. Begley, Jarod Oldham, Lewis Harrison, Jessee Hunt, Robert L. Mauck, Su Chin Heo   +9 more
wiley   +1 more source

SATURN: assessing the feasibility of utilising existing registries for real-world evidence data collection to meet patients, regulatory, health technology assessment and payer requirements

Orphanet Journal of Rare Diseases
Background SATURN (Systematic Accumulation of Treatment practices and Utilisation, Real world evidence, and Natural history data) for the rare condition osteogenesis imperfecta (OI) has the objective to create a common core dataset by utilising existing,
L. Sangiorgi, M. Boarini, M. Mordenti, V. Wang, I. Westerheim, R. T. Skarberg, M. Cavaller-Bellaubi, James Clancy, R. Pinedo-Villanueva, E. J. V. Lente, M. Marchetti   +10 more
doaj   +1 more source

Ultra‐Tiny Gelatin Nanoparticles‐Assisted 3D Stem Cell Spheroids for Engineering Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
GNPs effectively guide the formation of structurally compact and functionally enhanced stem cell spheroids. This GNP‐assisted 3D culture system improves cell–cell and cell‐ECM interactions, leading to superior viability and complexity. Time‐dependent regenerative potential is demonstrated in both bone and skin defects, positioning GNP‐spheroids as a ...
Dream Kim, Woochan Kim, Harshita Sharma, Shinyull Lee, Chaeyeon Park, Sunho Park, Chan Yeong Heo, Jangho Kim   +7 more
wiley   +1 more source

HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes [PDF]

, 2007
HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown. Here we show that HOXA10 contributes to osteogenic lineage determination through activation of Runx2 ...
Hassan, MQ, Lee, SH, Lian, JB, Mandeville, M, Montecino, M, Stein, GS, Stein, JL, Tare, R., van Wijnen, AJ, Weiner, B   +9 more
core   +3 more sources

Biomimetic Scaffolds with Dual Gradients of Biological Effectors for Tendon‐to‐Bone Repair

Advanced Healthcare Materials, EarlyView.
The authors have developed a biomimetic scaffold with dual gradients through a diffusion‐driven method. The scaffold features funnel‐shaped microchannels for cell infiltration, while the dual gradients synergetically induce the graded differentiation of mesenchymal stem cells into osteoblasts, chondrocytes, and tenocytes, allowing for a seamless ...
Min Hao, Yidan Chen, Stavros Thomopoulos, Younan Xia   +3 more
wiley   +1 more source

Rigidity of silicone substrates controls cell spreading and stem cell differentiation. [PDF]

, 2016
The dependences of spreading and differentiation of stem cells plated on hydrogel and silicone gel substrates on the rigidity and porosity of the substrates have recently been a subject of some controversy.
Groisman, Alex, Gutierrez, Edgar, Lee, Sin-Ae, Ronan, Edward, Tkachenko, Eugene, Vertelov, Grigory   +5 more
core   +2 more sources