Results 161 to 170 of about 165,191 (338)

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

OSTEOGENESIS IN THE OSTEOARTHRITIC FEMORAL HEAD

, 1973
1. Osteogenesis in the osteoarthritic femoral head has been examined with radioactive 32P and tetracycline bone markers. 2. In advanced osteoarthritis considerable osteogenic activity was observed, particularly in osteophytes, around cysts and in some ...
A. K. Jeffery
core   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

A Programmable Braided Silk‐Glass Fiber Ligament Promoting Rapid Motoric Recovery

Advanced Science, EarlyView.
A scalable three‐dimensional braiding strategy integrates silk and glass fibers into customizable artificial ligaments with programmable “J‐shaped” nonlinear mechanics. The silk‐rich architecture supports osseoligamentous integration, while glass fibers provide mechanical reinforcement and biomimetic mineralization cues, enabling strain‐adaptive load ...
Changbo Lu, Daming Liu, Haoxin Zhang, Zhiwei Qiao, Qiuming Gao, Jia Meng, Hongyin Yue, Songkai Li, Shuo Zhang, Tao Yuan, Yun Xue, Hui Jiang, Zhenguo Liu, Yibo Wang, Nirong Bao, Yuli Chen, Xiaojiang Yang   +16 more
wiley   +1 more source

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

Therapy with pamidronate in children with osteogenesis imperfecta

, 2017
Otilia Marginean,1 Raluca Corina Tamasanu,1 Niculina Mang,1 Ioana Mozos,2,3 Giorgiana Flavia Brad1 1First Department of Pediatrics, 2Department of Functional Sciences, 3Center for Translational Research and Systems Medicine, “Victor Babes&rdquo ...
Mozos I, Tamasanu RC, Marginean O, Mang N, Brad GF   +4 more
core  

FKBP5 promotes osteogenic differentiation of mesenchymal stem cells through type-I interferon pathway Inhibition

Cellular and Molecular Life Sciences
The decreased osteogenesis of bone marrow mesenchymal stem cells (BMSCs) is an important factor causing bone loss. Nevertheless, its deep molecular mechanism has still not been fully clarified.
Jun Tang, Ming Li, Yuanquan Chen, Yuwei Liang, Wenbin Yan, Qing Ning, Hao Deng, Huatao Liu, Yuxi Li, Lin Huang   +9 more
doaj   +1 more source

Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer

, 2015
Yanrong Cai,1 Lieping Guo,2 Hongxing Shen,2 Xiaofei An,2 Hong Jiang,3 Fang Ji,2 Yunfei Niu21The College of Basic Science of Medicine, Hunan University of Traditional Chinese Medicine, Changsha, 2Department of Orthopaedics, Changhai Hospital, Second ...
Guo L, Ji F, Cai Y, An X, Shen H, Jian H, Niu Y   +6 more
core  

The effect of a bionic bone ionic environment on osteogenesis, osteoimmunology, and in situ bone tissue engineering

Bone, a mineralized tissue, continuously undergoes remodeling. It is a process that engages the mineralization and demineralization of the bone matrix, orchestrated by the interactions among cells and cell-secreted biomolecules under the bone ionic ...
Du, Zhibin, Mu, Yuqing, Xiao, Lan, Crawford, Ross, Xiao, Yin, Gao, Wendong   +5 more
core   +1 more source

Leader genes in osteogenesis: a theoretical study

, 2013
Little is still known about the molecular mechanisms involved in the process of osteogenesis. In this paper, the leader genes approach, a new bioinformatics method which has already been experimentally validated, is adopted in order to identify the genes
Giacomelli, Luca, Covani, Ugo, Orlando, Bruno, Barone, Antonio, Ricci, Massimiliano   +4 more
core   +1 more source