Helical mutations in type I collagen that affect the processing of the amino-propeptide result in an Osteogenesis Imperfecta/Ehlers-Danlos Syndrome overlap syndrome [PDF]
, 2013 Background: Whereas mutations affecting the helical domain of type I procollagen classically cause Osteogenesis Imperfecta (OI), helical mutations near the amino (N)-proteinase cleavage site have been suggested to result in a mixed OI/Ehlers-Danlos ...
De Paepe, Anne +9 more
core +2 more sources
Pan African Medical Journal, 2021 Osteogenesis imperfecta is a rare hereditary connective tissue disorder that affects the bones fragility. It causes the bones to break easily. The defective gene affects the body mechanism to form collagen, which strengthens the bone. A 20-year-old male patient came with complaints of pain in the left leg since morning.
Surya Besant Natarajan +1 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2021 Osteogenesis imperfecta is a genetic disorder disrupting bone development and remodeling. The primary causes of osteogenesis imperfecta are pathogenic variants of collagen and collagen processing genes.
Christopher L. Schwebach +2 more
doaj +1 more source
Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds. [PDF]
, 2012 Implants formed of metals, bioceramics, or polymers may provide an alternative to autografts for treating large bone defects. However, limitations to each material motivate the examination of composites to capitalize on the beneficial aspects of ...
Genetos, Damian C +4 more
core +4 more sources
Enhanced Osteogenesis of Adipose-Derived Stem Cells by Regulating Bone Morphogenetic Protein Signaling Antagonists and Agonists. [PDF]
, 2016 UnlabelledAlthough adipose-derived stem cells (ASCs) are an attractive cell source for bone tissue engineering, direct use of ASCs alone has had limited success in the treatment of large bone defects.
Aghaloo, Tara L +11 more
core +2 more sources
Cephalometric studies of the mandible, its masticatory muscles and vasculature of growing Göttingen Minipigs — A comparative anatomical study to refine experimental mandibular surgery [PDF]
, 2019 Over many decades, the Göttingen Minipig has been used as a large animal model in experimental surgical research of the mandible. Recently several authors have raised concerns over the use of the Göttingen Minipig in this research area, observing ...
Corte, Guiliano Mario +4 more
core +3 more sources
Temperature responsiveness of gilthead sea bream bone; an in vitro and in vivo approach [PDF]
, 2018 This study aimed to characterize the molecules involved in osteogenesis in seabream and establish using in vitro/in vivo approaches the responsiveness of selected key genes to temperature.
Capilla, Encarnacion +8 more
core +3 more sources
Bleeding assessment in a large cohort of patients with Osteogenesis Imperfecta
Orphanet Journal of Rare DiseasesBackground Osteogenesis Imperfecta (OI) is characterised by bone fragility. Among several features, easy bruising and multiple case reports on haemorrhagic events have been reported.
Koert Gooijer +5 more
doaj +1 more source
Pregnancies complicated by maternal osteogenesis imperfecta type III: a case report and review of literature. [PDF]
, 2018 The restrictive lung disease can be exacerbated by growing fundus in women with osteogenesis imperfecta type III. Regional anesthesia can be performed in these women.
Al-Kouatly, Huda B. +3 more
core +1 more source
Multiscale Structuring of Hydroxyapatite via Two‐Photon Lithography of Nanocomposites
Advanced Functional Materials, EarlyView.Hydroxyapatite scaffolds are of great interest in bone tissue engineering applications, ranging from 3D cell culture to regenerative medicine. Using two‐photon lithography of a transparent nanocomposite, hydroxyapatite microstructures with features ranging from submicron to centimeter‐scale are fabricated. This allows to mimic the natural bone geometry,
Leonhard Hambitzer +6 more
wiley +1 more source