Results 101 to 110 of about 138,476 (311)

Knockdown of human-specific lncRNA MEK6-AS1 improves osteogenic differentiation of senescent mesenchymal stem cells [PDF]

Jichu yixue yu linchuang
Objective To investigate the role of a novel human-specific long noncoding RNA (lncRNA), MEK6-AS1, and its potential molecular mechanism in improving the osteogenic differentiation of senescent mesenchymal stem cells (MSCs).
CHEN Yunhua, LI Di, ZHAO Xiaoyan, CHEN Ming, LI Hongling, ZHAO Chunhua
doaj   +1 more source

Enhanced Osteogenesis of Adipose-Derived Stem Cells by Regulating Bone Morphogenetic Protein Signaling Antagonists and Agonists. [PDF]

, 2016
UnlabelledAlthough adipose-derived stem cells (ASCs) are an attractive cell source for bone tissue engineering, direct use of ASCs alone has had limited success in the treatment of large bone defects.
Aghaloo, Tara L, Bezouglaia, Olga, Cui, Zhong-Kai, Fan, Jiabing, Fartash, Armita, Guo, Mian, Im, Choong Sung, Kim, Soyon, Lee, Min, Patel, Nikhil, Wang, Cun-Yu, Wu, Benjamin M   +11 more
core   +2 more sources

Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues

Advanced Healthcare Materials, EarlyView.
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman, Hadas Oved, Itay Gil, Amgad Marzook, Ester Sapir Baruch, Yahel Shechter, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Caspase-independent programmed cell death triggers Ca2PO4 deposition in an in vitro model of nephrocalcinosis [PDF]

, 2018
We provide evidence of caspase-independent cell death triggering the calcification process in GDNF-silenced HK-2 ...
Anglani F., Ceol M, Cristofaro R, Del Prete D, Furlan C, Gianesello L, Priante G, Quaggio F, Terrin L   +8 more
core   +1 more source

Controlling Osteogenic Differentiation through Nanoporous Alumina

Journal of Biomaterials and Nanobiotechnology, 2014
Nanotopographical features are found to have significant effects on bone behavior. In the present study, nanoporous aluminas with different pore sizes (20, 100 and 200 nm in diameter), were evaluated for their osteoinductive and drug eluting properties. W20-17 marrow stromal cells were seeded on nanoporous alumina with and without the addition of BMP-2.
Shiuli Pujari-Palmer, Thomas Lind, Wei Xia, Liping Tang, Marjam Karlsson Ott   +4 more
openaire   +2 more sources

Ti6Al4V‐Bioglass‐Copper Composites for Load‐Bearing Implants

Advanced Healthcare Materials, EarlyView.
We have designed and manufactured a novel Ti64‐based composite by adding 45S5 bioglass (BG) and copper (Cu). Adding BG on titanium improves wear resistance and biocompatibility, whereas Cu addition improves mechanical strength while providing inherent lifelong bacterial resistance.
Lochan Upadhayay, Bryson White, Susmita Bose, Amit Bandyopadhyay   +3 more
wiley   +1 more source

Characterisation of Embryonic Dermal Precursor Cells [PDF]

, 2018
Skin is an attractive organ for the acquisition of stem cells due to its accessibility, size and potential for autologous transplants. Research into skin development has implications for the isolation of stem cell populations, for example skin-derived ...
BLINCKO, SARAH
core  

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

Circular RNA GCLC promotes osteogenic differentiation of bone marrow mesenchymal stem cells via modulating miR-516b-5p/GNAS axis

Journal of Orthopaedic Surgery and Research
Objective Osteoporosis (OP) is a systemic bone disease without effective treatment at present. The aim of this study is to explore the role of the circular RNA GCLC (circGCLC) in the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs)
An Li, Sheng Zhang, Jing Zhang, Zhihua Peng, Qinghui Feng   +4 more
doaj   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source