Results 191 to 200 of about 46,379 (288)

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Targeting AHNAK ameliorates osteonecrosis of the femoral head and affects adipogenic pathways involving Smad/PPARγ. [PDF]

Bone Joint Res
Chen MF, Hu CC, Hsiao YM, Jiang PH, Hsu YH, Wu CY, Ueng SWN, Chang Y.   +7 more
europepmc   +1 more source

A combined radiomics‐clinical nomogram for assessing MRI‐defined femoral Head collapse status in osteonecrosis of the femoral Head

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background Osteonecrosis of the femoral head (ONFH) frequently progresses to femoral head collapse, resulting in irreversible joint dysfunction and the need for total hip arthroplasty. Reliable assessment of magnetic resonance imaging (MRI)‐defined collapse status remains limited with conventional assessment methods.
Lijun Peng, Yi Zhou, Lihua Zhou
wiley   +1 more source

Functional recovery after open talar neck fracture with foot dislocation: A case report. [PDF]

Trauma Case Rep
Labmayr V, Huetter K, Ornig M, Lanz P, Puchwein P, Holweg P.   +5 more
europepmc   +1 more source

Fracture Risk Associated With Long‐Term Discontinuation of Postmenopausal Osteoporosis Treatment: A French Population‐Based Study Using National Claims Data (Système National des Données de Santé)

ACR Open Rheumatology, Volume 8, Issue 9, September 2026.
Objective This retrospective cohort study evaluated the long‐term discontinuation (LTD) of osteoporosis treatments in postmenopausal women in France and associated fracture risk and economic burden. Methods From the national French health care database (Système National des Données de Santé), we included postmenopausal women aged ≥60 years initiating ...
Audrey Lajoinie, Meriem Benmerad, Magali Laborey, Pascale Samama, Gaëlle Désaméricq, Leila Chelbani, Karine Briot   +6 more
wiley   +1 more source

Case Report: Systemic Lupus Erythematosus Complicated by Chronic Nonbacterial Osteitis: A Rare Case Report and Mechanistic Insights. [PDF]

Int J Rheum Dis
Xu L, Chen Z, Fang C, Xu D.
europepmc   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Immunomodulation in the repair of osteonecrosis of the femoral head: reprogramming strategies for macrophages and immune cells. [PDF]

Front Immunol
Han L, Han M, Hou W, Luo G, Tian L, Li M, Su H, He M, Yang F, He W, Wei Q.   +10 more
europepmc   +1 more source

Adjunctive Hyperbaric Oxygen Therapy for a Refractory Sickle Cell‐Associated Leg Ulcer: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Sickle cell leg ulcers (SCLUs) are a chronic and debilitating complication of sickle cell disease (SCD), often associated with severe pain, impaired mobility, delayed healing, and recurrence. Their management remains challenging because ulcer formation and persistence are driven by multiple overlapping mechanisms, including hemolysis ...
Jamil Wafi, Awni Alshurafa, Mohamed A. Yassin   +2 more
wiley   +1 more source

Retrospective cohort study assessing radiological outcomes and risk factors for progression of femoral head osteonecrosis in children with sickle cell disease, following bisphosphonate therapy, CD-BMAC and proximal femoral reorientation osteotomy. [PDF]

J Child Orthop
Elayedatt RA, Gahukamble AD, A AM, Thuppale VE, Abraham A, Kandagaddala M, Palocaren T.   +6 more
europepmc   +1 more source