Results 81 to 90 of about 44,473 (251)

Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis

Med Research, EarlyView.
The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang, Yanyun Pang, Peijia Zhu, Zhengdong Zhang, Sen Guo, Zhijian Wei, Wenzhao Wang, Bin Ning   +7 more
wiley   +1 more source

Factors associated with dislocation after total hip arthroplasties performed for nontraumatic osteonecrosis of the femoral head: a multicenter cohort study of 5,983 hips

Acta Orthopaedica
Background and purpose: Nontraumatic osteonecrosis of the femoral head (ONFH) patients are at a higher dislocation risk after primary total hip arthroplasties (THAs) than osteoarthrosis patients.
Seneki Kobayashi, Nobuhiko Sugano, Wataru Ando, Wakaba Fukushima, Kyoko Kondo, Takashi Sakai   +5 more
doaj   +1 more source

Bone mineral content after renal transplantation [PDF]

, 1984
Forearm bone mineral content (BMC), as evaluated by photonabsorption densitometry, was measured in 28 cadaver kidney donor recipients who entered the study 8 weeks postoperatively and were followed up for 18 months.
A Alvestrand, A Alvestrand, E Ritz, E. Neubauer, E. Ritz, EGA Aird, F Suzuki, HE Nielsen, HK Genant, I Yoshihiro, J Lekkerkerker, JK Davidson, JU Lindgren, K. -H. Krause, K. Dreikorn, KD Tovey, LS Ibels, MG McGeown, N. Neubauer, R Bouillon, R Lindsay, RE Belsey, RG Klein, TJ Hahn, TJ Hahn, TJ Hahn, TJ Hahn, WE Huffer, WSS Jee   +28 more
core   +1 more source

Long‐Term Clinical Outcome and Quality of Life of Children, Adolescents, and Young Adults With Chordoma or Chondrosarcoma Treated With Pencil Beam Scanning Proton Therapy

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims To assess clinical outcomes and quality of life (QoL) of children, adolescents, and young adults (C‐AYAs) with chordomas (CH) or chondrosarcomas (CS) after pencil beam scanning proton therapy (pbsPT). Methods A total of 76 C‐AYAs treated between 1999 and 2023 were included. Median age was 16.6 years (1.5–25.4).
Miriam Vazquez, Alexey Cherchik, Claudio de Angelis, Alessia Pica, Gabriele Calaminus, Damien C. Weber   +5 more
wiley   +1 more source

Knee loading protects against osteonecrosis of the femoral head by enhancing vessel remodeling and bone healing [PDF]

, 2015
Osteonecrosis of the femoral head is a serious orthopedic problem. Moderate loads with knee loading promote bone formation, but their effects on osteonecrosis have not been investigated.
Li, Jie, Li, Xinle, Liu, Daquan, Yang, Jing, Yokota, Hiroki, Zhang, Ping   +5 more
core   +1 more source

Complications at Diagnosis of Pediatric Chronic Myeloid Leukemia in Chronic Phase

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Chronic myeloid leukemia (CML) is uncommon during the first two decades of life, resulting in limited experience of pediatricians in handling this leukemia. This is even more true when it comes to managing rare complications at the time of diagnosis.
Nirmalya Roy Moulik, Uma Athale, Markus Metzler, Frederic Millot, Meinolf Suttorp   +4 more
wiley   +1 more source

Analysis of m6A regulators related immune characteristics in ankylosing spondylitis by integrated bioinformatics and computational strategies

Scientific Reports
N6-methyladenosine (m6A) modification, as a common epigenetic modification, has been widely studied in autoimmune diseases. However, the role of m6A in the regulation of the immune microenvironment of ankylosing spondylitis (AS) remains unclear ...
Da Guo, Jiayi Liu, Shuang Li, Peng Xu
doaj   +1 more source

Construction and validation of steroid-induced rabbit osteonecrosis model

MethodsX, 2022
Osteonecrosis is a common orthopedic disease in clinic, resulting in joint collapse if appropriate treatment is not given in time. The clinical usage of high-dose steroid is one of the common causes of osteonecrosis.
Tongtong Zhu, Mengyang Jiang, Mingran Zhang, Liguo Cui, Xiaoyu Yang, Xukai Wang, Guangyao Liu, Jianxun Ding, Xuesi Chen   +8 more
doaj  

Analysis of different therapeutic protocols for osteonecrosis of the jaw associated with oral and intravenous bisphpsphonates [PDF]

, 2016
Chemotherapy-associated osteonecrosis of the jaw caused by bisphosphonates is an exposure of necrotic bone with more than eight weeks of evolution that is attributable to bisphosphonates and no prior radiation therapy.
Bermúdez Bejarano, Elena Beatriz, Castillo de Oyagüe, Raquel, Gutiérrez Corrales, Aida, Gutiérrez Pérez, José Luis, Machuca Portillo, Guillermo, Romero Ruiz, Manuel María, Serrera Figallo, María Angeles, Torres-Lagares, Daniel   +7 more
core   +2 more sources

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

Small Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli, Annie Y. Heble, Connor Endsley, Adam Woodward, Nazia Hafeez, Naomi Winick, Jacques Lux   +6 more
wiley   +1 more source