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Osteonectin, a bone-specific protein linking mineral to collagen
Cell, 1981Osteonectin is a 32,000 dalton bone-specific protein that binds selectively to both hydroxyapatite and collagen. When osteonectin is bound to insolubilized type I collagen, the resultant complex binds synthetic apatite crystals and free calcium ions. The osteonectin-collagen complexes also nucleate mineral phase deposition from metastable balanced salt
J D, Termine +5 more
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Osteonectin (SPARC) prognostic value in prostate cancer
Pathology - Research and PracticeProstate cancer (PCa) is common malignancy among men worldwide. To date only few molecular markers are available to predict its course and outcome. SPARC is considered to be promising prognostic marker of PCa due to its involvement in various cancer processes.study was conducted on PCa surgical primary tumor samples, obtained from 84 patients. Level of
Vasyl, Chekhun +6 more
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Osteonectin is a minor component of mineralized connective tissues in rat
Biochemistry and Cell Biology, 1986Osteonectin is a major glycoprotein of porcine and bovine bones and teeth that is found associated with hydroxylapatite crystal surfaces. From the ability of osteonectin to bind calcium ions, it has been proposed as a possible nucleator of hydroxylapatite crystal formation.
P, Zung +4 more
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Valproate reduces collagen and osteonectin in cultured bone cells
Epilepsy Research, 2013Valproate is a histone deacetylase (HDAC) inhibitor that was introduced more than 40 years ago and is commonly used to treat epilepsy and mood disorders. Its long-term side effects can include bone loss, although the exact mechanism for this is currently unknown.
Emma L, Humphrey +2 more
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Circulating levels of osteonectin in normal subjects and patients with thrombocytopenia
Bone and Mineral, 1990In order to clarify the relative contributions of activated platelets and other sources to circulating osteonectin, the amounts of osteonectin present in serum and in plasma prepared without significant platelet activation were compared to platelet count in normal subjects and patients with various degrees of thrombocytopenia.
L, Malaval, M, Ffrench, P D, Delmas
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The osteonectin family of proteins
International Journal of Biochemistry, 1988R P, Tracy +3 more
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Biosynthesis, properties and distribution of osteonectin
Bone, 1985Jaro Sodek +3 more
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