Results 171 to 180 of about 7,635 (213)

Characterization of Sparus aurata osteonectin cDNA and in silico analysis of protein conserved features: Evidence for more than one osteonectin in Salmonidae

Biochimie, 2005
Osteonectin is a matricellular protein involved in various cellular mechanisms but its exact function remains unclear despite numerous studies. We present here the cloning of Sparus aurata partial osteonectin cDNA and the reconstruction of 15 other sequences from both vertebrates and invertebrates, almost doubling the set of available sequences (a ...
Vincent Laize, Antonio R Pombinho, M Leonor Cancela   +2 more
exaly   +5 more sources

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Osteonectin ? a differentiation marker of bone cells

Cell and Tissue Research, 1987
Bone matrix consists of type-I collagen and non-collagenous proteins. The latter represent only 10% of its total protein content. Since type-I collagen is also present in various other connective tissue sites (e.g., skin) it cannot be considered as bone specific.
G Jundt, John D Termine
exaly   +3 more sources

Valproate reduces collagen and osteonectin in cultured bone cells

Epilepsy Research, 2013
Valproate is a histone deacetylase (HDAC) inhibitor that was introduced more than 40 years ago and is commonly used to treat epilepsy and mood disorders. Its long-term side effects can include bone loss, although the exact mechanism for this is currently unknown.
Emma L, Humphrey, Glenn E, Morris, Heidi R, Fuller   +2 more
openaire   +3 more sources

Novel Functions of the Matricellular Proteins Osteopontin and Osteonectin/SPARC

Connective Tissue Research, 2002
Osteopontin (OPN) and osteonectin/SPARC (ON/SPARC) are prominent matricellular components of the extracellular matrix of mineralized tissues of bones and teeth in which they can regulate the formation and growth of hydroxyapatite crystals and influence a variety of cell activities.
Jaro Sodek, My-Hang Huynh, Theodore J Brown   +2 more
exaly   +3 more sources

Osteonectin, a bone-specific protein linking mineral to collagen

Cell, 1981
Osteonectin is a 32,000 dalton bone-specific protein that binds selectively to both hydroxyapatite and collagen. When osteonectin is bound to insolubilized type I collagen, the resultant complex binds synthetic apatite crystals and free calcium ions. The osteonectin-collagen complexes also nucleate mineral phase deposition from metastable balanced salt
John D Termine, Hynda K Kleinman, George R Martin   +2 more
exaly   +3 more sources

Osteonectin downregulates E‐cadherin, induces Osteopontin and Focal adhesion kinase activity stimulating an invasive melanoma phenotype

International Journal of Cancer, 2007
Osteonectin is recognised as a marker of metastasis progression in melanoma and has been implicated in the transition from radial to vertical growth phase.
Darren J Smit, Brooke Gardiner, Richard A Sturm   +2 more
exaly   +2 more sources

Osteonectin expression correlates with clinical outcome in thin cutaneous malignant melanomas

Human Pathology, 1999
OSTEONECTIN EXPRESSION CORRELATES WITH CLINICAL OUTCOME IN THIN CUTANEOUS MALIGNANT ...
Lorenzo Borgognoni, Marco Santucci
exaly   +1 more source

Osteonectin gene expression in fibrotic liver

Life Sciences, 1996
Osteonectin is an extracellular matrix (ECM) protein which is secreted by various cell types, and regulates tissue remodeling and cell proliferation. In the present study, we have examined the expression of osteonectin in fibrotic liver. Osteonectin transcripts were undetectable in normal liver, however, the abundant expression of the osteonectin gene ...
H, Inagaki, K H, Lin, S, Maeda, T, Saito
openaire   +2 more sources

Isolation of the osteonectin gene: evidence that a variable region of the osteonectin molecule is encoded within one exon

Biochemistry, 1988
A complementary DNA clone for bovine osteonectin was used to isolate the osteonectin gene from two libraries of bovine genomic DNA fragments. Two overlapping clones were obtained whose relationship was determined by restriction mapping and sequence analysis. The two clones contain the entire osteonectin coding region spanning approximately 11 kilobases
D M, Findlay, L W, Fisher, C I, McQuillan, J D, Termine, M F, Young   +4 more
openaire   +2 more sources

Purification ofSPARC/Osteonectin

Current Protocols in Cell Biology, 2003
AbstractSPARC is a matricellular protein that regulates cell adhesion, extracelluolar matrix production, growth factor activity and cell cycle. This unit describes the purification of SPARC, also termed osteonectin and BM/40, from cultured mammalian cells.
openaire   +2 more sources