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SPARC (osteonectin/BM-40)

The International Journal of Biochemistry & Cell Biology, 1999
SPARC (Secreted ProteinAcidic and Rich in Cysteine) is a prototype of a family of biologically active glycoproteins that bind to cells and to extracellular matrix (ECM) components. It is expressed spatially and temporally during embryogenesis, tissue remodeling and repair.
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Osteonectin/SPARC is overexpressed in human hepatocellular carcinoma

The Journal of Pathology, 1999
Osteonectin (ON)/SPARC is a glycoprotein involved in extracellular matrix remodelling. ON expression by myofibroblasts has been reported in fibrotic human liver. As ON also plays a role in cell adhesion, differentiation, and proliferation, this study was designed to document its expression in human hepatocellular carcinoma (HCC).
B, Le Bail   +8 more
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Immunological screening of SPARC/Osteonectin in nonmineralized tissues

Bone, 1992
SPARC/Osteonectin is a major bone-related protein that is also present in nonmineralized tissues and in platelets. As compared to bone SPARC/Osteonectin, SPARC/Osteonectin from platelets presents a slightly lower electrophoretic mobility in SDS-PAGE and a 100-fold decreased affinity for a unique monoclonal antibody, Mab2 (Malaval et al. 1991). To check
C, Maillard, L, Malaval, P D, Delmas
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Osteonectin (SPARC) prognostic value in prostate cancer

Pathology - Research and Practice
Prostate cancer (PCa) is common malignancy among men worldwide. To date only few molecular markers are available to predict its course and outcome. SPARC is considered to be promising prognostic marker of PCa due to its involvement in various cancer processes.study was conducted on PCa surgical primary tumor samples, obtained from 84 patients. Level of
Vasyl, Chekhun   +6 more
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Osteonectin is a minor component of mineralized connective tissues in rat

Biochemistry and Cell Biology, 1986
Osteonectin is a major glycoprotein of porcine and bovine bones and teeth that is found associated with hydroxylapatite crystal surfaces. From the ability of osteonectin to bind calcium ions, it has been proposed as a possible nucleator of hydroxylapatite crystal formation.
P, Zung   +4 more
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The osteonectin family of proteins

International Journal of Biochemistry, 1988
R P, Tracy   +3 more
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Osteonectin BM40, SPARC

1998
Shirley Ayad   +4 more
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Biosynthesis, properties and distribution of osteonectin

Bone, 1985
Jaro Sodek   +3 more
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