Results 81 to 90 of about 75,261 (235)

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, EarlyView.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Sarcopenia, Bone Mineral Density, and Vitamin D: Epifloripa Aging Study 2013/2014 [PDF]

Geriatrics, Gerontology and Aging
OBJECTIVE: To verify associations between osteopenia/osteoporosis and vitamin D and sarcopenia in the older adult population of Florianópolis, Brazil. METHODS: A cross-sectional population-based study, with 604 older adults (60 years and over).
Susana Cararo Confortin, Lariane Mortean Ono, Larissa Pruner Marques, Thamara Hubler Figueiró, Gilciane Ceolin, Aline Rodrigues Barbosa, Eleonora d'Orsi   +6 more
doaj   +1 more source

Body composition, IGF1 status, and physical functionality in nonagenarians: implications for osteosarcopenia [PDF]

, 2018
OBJECTIVES: Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in ...
Cherry, Ke, Jazwinski, Sm, Kim, S, Myers, L, Poggiogalle, E, Ravussin, E., Su, Lj, Welsh, Da   +7 more
core  

Mechanisms underlying bone loss associated with gut inflammation [PDF]

, 2019
Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation.
Abu-Amer, Yousef, Arra, Manoj, Ke, Ke
core   +2 more sources

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Clinical impact of low bone mineral density in patients with colorectal cancer liver metastasis undergoing hepatectomy.

PLoS ONE
BackgroundThis study aimed to elucidate the clinical impact of osteopenia on the recurrence of colon cancer liver metastases.MethodsPatients with colon cancer liver metastases (N = 186) undergoing hepatectomy at Jichi Medical University Hospital between ...
Yuichi Aoki, Atsushi Miki, Yasunaru Sakuma, Jun Watanabe, Takehiro Kagaya, Makiko Tahara, Takumi Teratani, Kazuhiro Endo, Hideki Sasanuma, Wataru Nishimura, Hisanaga Horie, Joji Kitayama, Naohiro Sata, Hironori Yamaguchi   +13 more
doaj   +1 more source

Serum markers of bone fragility in type-2 diabetes mellitus [PDF]

, 2019
Patients with type-2 diabetes mellitus (T2DM) have normal or increased bone mineral density (BMD) but despite that, they are characterized by an increased hip and vertebral fracture risk that involves the alteration of bone quality and not the reduction ...
Dănciulescu Miulescu, Rucsandra, Guja, Loreta, Ochiana, Lavinia Claudia, Ungurianu, Anca, Șeremet, Oana Cristina, Ștefănescu, Emil   +5 more
core   +1 more source

Expanding Phenotype of GINS1 Deficiency: A Case Report and Review of the Literature

Clinical Genetics, EarlyView.
The authors present a novel case and review of individuals with GINS1 deficiency, causing severe growth restriction and combined immunodeficiency. Only the ninth case of this ultrarare disorder, it highlights the role of these variants in disease, glaucoma as a feature, and the possibility of immunodeficiency without infections in affected individuals.
Michael P. Mackley, Rae Brager, Hannah Geddie, Vicky Breakey, Rebecca Hough, Dimitrios J. Stavropoulos, Vanda McNiven   +6 more
wiley   +1 more source

Marked Subchondral Bandlike Osteopenia on Radiography after Trauma and Inactivity: A Report of four Cases

Case Reports in Orthopedics, 2013
We report about four cases of marked subchondral osteopenia on followup radiography after trauma and prolonged disuse. This localized form of disuse osteopenia has not been reported in details beside the followup imaging of talar neck fractures, where it
J. Gossner, B. W. Raab, J. Larsen, S. Breitkreuz   +3 more
doaj   +1 more source

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, EarlyView.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source