Results 181 to 190 of about 75,213 (253)

The fat-heart entanglement and the role of 'osteopontin mechanics' in cardiometabolic senescence. [PDF]

Eur J Clin Invest
Michelauz C, Montecucco F, Liberale L, Carbone F.   +3 more
europepmc   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, Volume 13, Issue 22, 17 April 2026.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Transcriptome Analysis Identified <i>SPP1</i>-Positive Monocytes as a Key in Extracellular Matrix Formation in Thrombi. [PDF]

J Am Heart Assoc
Kitano T, Sasaki T, Matsui T, Kohara M, Ogawa K, Todo K, Nakamura H, Sugiura Y, Shimada Y, Okazaki S, Iida J, Shimazu K, Morii E, Sakaguchi M, Nishio M, Yokoe M, Kishima H, Mochizuki H.   +17 more
europepmc   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

Loss of Nonhematopoietic Osteopontin Weakens the Intestinal Barrier and Alters the Microbiome and Metabolome in Mice. [PDF]

Gastro Hep Adv
Hirano T, Wagatsuma K, Shimomori Y, Akita K, Nakamura T, Yamakawa T, Yokoyama Y, Kurumi H, Ishigami K, Nagaishi K, Nakase H.   +10 more
europepmc   +1 more source

Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival [PDF]

, 2017
Gutmann, David H, Hambardzumyan, Dolores, Ma, Yu, Pan, Yuan, Smithson, Laura J   +4 more
core   +2 more sources

Dual‐Strategy Design of Heterojunction‐Enhanced Piezoelectric Hydrogels for Periodontitis Treatment

Advanced Science, Volume 13, Issue 22, 17 April 2026.
This study developed a piezoelectric hydrogel integrating heterojunction enhancement and dual‐salt synergy, combining robust electrical performance with mechanical stability and bioactivity to better match the periodontal microenvironment. Under ultrasound activation, the hydrogel markedly promotes macrophage M2 polarization, thereby reducing the ...
Qiangqiang Zhou, Shaojun Fang, Changyi Li, Mengqi Zhou, Xin Sui, Chen Hu, Huaxing Xu, Shiyi Yang, Bing‐Qiang Lu, Rongjun Zhang, Xiaoling Wei   +10 more
wiley   +1 more source

Novel biomarkers for early detection of HCC in patients with MASLD or ALD. [PDF]

Hepatol Commun
Deodhar S, Jarrah M, Parikh ND, Al-Hasan M, Gopal P, Singal AG.   +5 more
europepmc   +1 more source

Bone mechano-response is driven by locomotion transitions during vertebrate evolution. [PDF]

Commun Biol
Shimochi S, Brunet C, Fontcuberta-Rigo M, Hrovat K, Puigbò P, Nakamura M.   +5 more
europepmc   +1 more source

Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of studies using ADNI data (2023 to June 2025)

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract Alzheimer's disease (AD) continues to pose a major public health challenge. Since its launch in 2004, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has played a pivotal role in advancing the field by providing a comprehensive, open‐access, longitudinal dataset that integrates neuroimaging, biomarker, genetic, and clinical data related
Shaveta Kanoria, Dallas P. Veitch, Melanie J. Miller, Paul S. Aisen, Laurel A. Beckett, Robert C. Green, Danielle J. Harvey, Clifford R. Jack Jr., William Jagust, Edward B. Lee, Kwangsik Nho, Rachel Nosheny, Ozioma C. Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera Mindt, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun, Susan M. Landau, Michael W. Weiner, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source