Results 181 to 190 of about 54,052 (278)

Integrative Bioinformatics and Machine Learning Approaches for Biomarker and Pathway Discovery in Malignant Pleural Mesothelioma

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Malignant pleural mesothelioma (MPM) is a highly aggressive thoracic cancer with limited treatment options and poor prognosis. Aims This study employed an integrative transcriptomic and computational approach to uncover potential biomarkers for MPM.
Md. Lotifur Rohman, Suman Biswas
wiley   +1 more source

Non‐invasive biomarkers in biliary atresia: A scoping review of fibrosis assessment, translational readiness and clinical implementation gaps

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Biomarkers are positioned by their highest developmental stage. Most biomarkers remain in exploratory phases, with serum MMP‐7 and elastography showing the greatest translational maturity. This highlights the primary challenge is the transition from biomarker discovery to clinical implementation.
Elizabeth Brits, Stephen Brown, Lezelle Botes, Michael Pienaar   +3 more
wiley   +1 more source

Ductular reaction as a spatial fibrogenic niche: cholangiocyte-macrophage-fibroblast crosstalk in chronic liver disease. [PDF]

Front Med (Lausanne)
Wang K, Li L, Mei X, Gao H.
europepmc   +1 more source

Radiation‐induced AXL upregulation in CCR2+ monocytes promotes cardiac fibrosis

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
1. IR_D30 is characterised by established cardiac fibrosis and ongoing immune remodelling. 2. Cardiac CCR2+ monocytes accumulate after irradiation and contribute to fibroblast activation through paracrine signalling. 3. AXL contributes to this fibroblast‐activating activity, at least in part through MEK/ERK signalling. 4.
Ying‐Yi Li, Jian‐Qi Xiong, Zhi‐Hui Zhang, Xin Liu, Yi‐Xin Cheng, Yong‐Xin Chi, Guan‐Qiao Li, Wen‐Huan Zhong, Shuang Chen, Zhen‐Yu He   +9 more
wiley   +1 more source

Creation and characterization of novel knock-in mouse models of hypophosphatasia. [PDF]

JBMR Plus
Okawa R, Ochiai M, Kurosaka H, Kadota T, Takagi M, Suehiro Y, Okawa H, Naka S, Yamaguchi S, Horike SI, Daikoku T, Watanabe A, Matsumoto-Nakano M, Imazato S, Michigami T, Ozono K, Yamashiro T, Nakano K.   +17 more
europepmc   +1 more source

Predicting Relevant Microglia‐Associated Cell–Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1

Glia, Volume 74, Issue 10, October 2026.
We used CellChat to infer altered cell–cell communication in Alzheimer's disease Microglia signal to each other via SPP1 in Alzheimer's disease. SPP1‐expressing microglia are present around amyloid‐β plaques. ABSTRACT Microglia play a key role in the pathophysiology of Alzheimer's Disease (AD) and their increased heterogeneity likely affects disease ...
Janssen M. Kotah, Marina Trombetta Lima, Esmée C. Dragt, Asimenia Voulgaroglou, Nieske Brouwer, Inge R. Holtman, Susanne M. Kooistra, Bart J. L. Eggen   +7 more
wiley   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Longitudinally Monitoring Prostate Cancer Bone Metastasis and Treatment Response via Circulating Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
ABSTRACT Lethal prostate cancer (PCa) is dominated by treatment‐refractory progression in bone. In this study, we used plasma‐derived extracellular vesicles (EVs) for monitoring the tumour and therapy‐induced changes in the bone tumour microenvironment (bone‐TME) in men with bone metastatic PCa (M1b PCa).
Emanuela Gentile, Paul G. Corn, Martha Zavridou, James P. Long, Jian H. Song, Anh Hoang, Andrew W. Hahn, Eleonora Dondossola, William Norton, Sue‐Hwa Lin, Christopher J. Logothetis, Theocharis Panaretakis   +11 more
wiley   +1 more source

Editorial: 15 years of Frontiers in Cellular Neuroscience: exploring astrocyte heterogeneity: regional functions and impacts on diseases. [PDF]

Front Cell Neurosci
Falcone C, Petrelli F.
europepmc   +1 more source

Osteomyelitis: Epidemiology, Classification, Pathophysiology, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
The immunosuppressive in OM Staphylococcus aureus employs multiple physical barriers to evade host immunity during skeletal infection, including biofilm formation on implant surfaces and necrotic bone tissues, invasion into the osteocyte lacuno‐canalicular network (OLCN), intracellular persistence within osteoblasts, osteoclasts, and osteocytes, and ...
Qingqiang Lei, Liangbin Lin, Peidong Pu, Jie Chen, Xianchao Su, Shubao Liu, Yanli Tong, Hui Yu   +7 more
wiley   +1 more source