Results 191 to 200 of about 49,469 (298)

The Reconstitution of the Macrophage Niche Reveals Dynamic Transcriptional and Renal Macrophage-Epithelial Communication Networks. [PDF]

Cells
Islamuddin M, Ji L, Chen Y, Song K, Ellsworth CR, Rappaport J, Wang C, Liu S, Kolls J, Xu X, Qin X.   +10 more
europepmc   +1 more source

Injectable Porous Microspheres Loaded With Biomimetic Preconditioned Bone Marrow Mesenchymal Stem Cell‐Derived Exosomes for Vascularized Bone Regeneration

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Schematic illustration of injectable PDA‐modified GelMA microspheres loaded with BioPre‐Exos for vascularized bone regeneration. ABSTRACT Critical‐sized bone defects remain a highly challenging clinical problem due to insufficient intrinsic self‐healing capacity.
Lijun Li, Hao Zhang, Lingtong Sun, Yingfeng Su, Yang Xu, Jian Huang, Jingchao Wen, Jinjin Zhu, Jianjun Ma, Wenbin Xu   +9 more
wiley   +1 more source

Selected Serum Biomarkers in Patients with Relapsing-Remitting Multiple Sclerosis-A 3-Year Prospective Pilot Study. [PDF]

Med Sci (Basel)
Puz P, Maciejowska K, Gendosz de Carrillo D, Janik M, Lasek-Bal A.   +4 more
europepmc   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Milk-derived osteopontin influences the composition of the intestinal intraepithelial lymphocyte compartment. [PDF]

Immunohorizons
McClanahan KG, Capella J, Gaddy JA, Olivares-Villagómez D.   +3 more
europepmc   +1 more source

Exosome‐mediated miR‐4660 delivery inhibits OPN promoted hepatoma cells aggression through targeting LGALS3BP

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
miR‐4660 was found to be downregulated in exosomes derived from SMMC‐OPN cells, a stable HCC cell line that overexpresses OPN. LGALS3BP has been identified as a direct target of miR‐4660, with its expression levels elevated in both SMMC‐OPN cells and their secreted exosomes.
Cuihua Liu, Riwen An, Ting Lin, Lei Qu, Xiaopeng Zheng, Jingkun Lu, Mei Hong, Pengwei Zhao, Fangxin Zhao, Xuan Zhang   +9 more
wiley   +1 more source

Altered Senescence-Associated Secretory Phenotype of Human Osteoblasts from Patients with Osteoporosis Enhances Endothelial Cell Migration and Proliferation In Vitro. [PDF]

Biology (Basel)
Oezel L, Wergen NM, Zimmermann R, Popov S, Gürsoy B, Grassmann JP, Benölken N, Kuebart T, Bittersohl B, Grotheer V.   +9 more
europepmc   +1 more source

Osteogenic Differentiation Induced by Dental Pulp Stem Cells Secretome: A Dose‐Dependent Comparative Study

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives To investigate the effects of dental pulp stem cell‐derived conditioned medium (DPSC‐CM) on the proliferation, migration, and osteogenic differentiation of periodontal ligament stem cells (PDLSCs). Primary goals were to (i) identify the optimal DPSC‐CM' concentration and (ii) evaluate its effect both independently (under Growth ...
Mahdi Kadkhodazadeh, Reza Amid, Aida Kheiri, Sayna Shamszadeh, Forough Shams   +4 more
wiley   +1 more source

In-ovo supplementation with bovine milk osteopontin improves hatchability, chick quality, growth performance, and enhances intraepithelial lymphocyte populations in specific-pathogen-free layer chicks. [PDF]

Poult Sci
Shah BR, Majeed S, Khalid N, Arora P, Abdelaziz K, Nazmi A.   +5 more
europepmc   +1 more source

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source