Results 191 to 200 of about 99,821 (371)
Cancer Science, EarlyView.SPP1 was identified as a key driver of intratumoral fibrosis and hepatocellular carcinoma (HCC) progression through transcriptomic, histological, and functional analyses. Mechanistically, SPP1 promotes HSC activation and fibrosis via the SPP1–CD44–GLI1 axis, and pharmacologic inhibition of Hedgehog signaling effectively reduces tumor growth and ...
Atsushi Nara +16 more
wiley +1 more source
Supplementary Figure 3 from Osteopontin Promotes Vascular Endothelial Growth Factor–Dependent Breast Tumor Growth and Angiogenesis via Autocrine and Paracrine Mechanisms [PDF]
, 2023 Goutam Chakraborty +2 more
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Cell Proliferation, EarlyView.Our study demonstrated that TGF‐β1 activated MAPK signalling pathway and promoted the MMT and secretion of CCL17 under CD‐associated intestinal inflammatory conditions. AMSC‐sEVs can deliver MFGE8, which inhibits MMT and CCL17‐mediated Treg recruitment by suppressing the MAPK signalling pathway, thereby alleviating intestinal fibrosis.
Minghao Xie +6 more
wiley +1 more source
Differences in osteopontin up-regulation between proximal and distal tubules after renal ischemia/reperfusion [PDF]
, 1999 Veerle P. Persy +4 more
openalex +1 more source
Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases
Cell Proliferation, EarlyView.Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long +6 more
wiley +1 more source
Progesterone Regulates Osteopontin Expression in Human Trophoblasts: A Model of Paracrine Control in the Placenta? [PDF]
, 1997 Akinyinka Omigbodun
openalex +1 more source
Diabetic kidney disease, biomarkers, and finerenone
Diabetes, Obesity and Metabolism, EarlyView.Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley +1 more source
Alterations of bone proteins in medication‐related osteonecrosis of the jaw
European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert +6 more
wiley +1 more source