Results 91 to 100 of about 427,163 (354)

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, EarlyView.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

Real-world treatment and fracture incidence in postmenopausal women with severe osteoporosis at high risk of fracture: a retrospective claims data analysis

, 2021
Antje Mevius, Tanja Heidbrede, P Gille, Hans Derk Pannen, Thomas Wilke   +4 more
openalex   +1 more source

Markov Models for Economic Evaluation in Osteoporosis Treatment [PDF]

, 2021
Marta Osca Guadalajara, Javier Díaz-Carnicero, Silvia González-de-Julián, David Vivas-Consuelo   +3 more
openalex   +1 more source

Steap4 Promotes Senile Osteoporosis via Fe2+‐ROS/C/EBPβ Feedback‐Driven Ferroptosis and Adipogenesis in Senescent BMSCs

Advanced Science, EarlyView.
Senescent bone marrow mesenchymal stem cells (BMSCs) exhibit increased sensitivity to ferroptosis, a phenomenon associated with Steap4, a nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)‐dependent metalloreductase that reduces Fe3+ to Fe2+.
Liangliang Wang, Guangrong Yin, Wenming Li, Maoyuan Li, Feng Lu, Chao Xu, Gongyin Zhao, Dechun Geng, Jiaxiang Bai, Yuji Wang   +9 more
wiley   +1 more source

Guidelines for the Diagnosis and Treatment of Primary Osteoporosis (2022) [PDF]

Zhongguo quanke yixue, 2023
Chinese Society of Osteoporosis and Bone Mineral Research
doaj   +1 more source

Hand fracture epidemiology and etiology in children—time trends in Malmö, Sweden, during six decades

Journal of Orthopaedic Surgery and Research, 2019
Background The aim of this study was to describe hand fracture epidemiology/etiology in city children and describe time trend during six decades. Patients and methods A single hospital serves the entire city population of 271,271 (year 2005). Through the
Vasileios Lempesis, Björn E. Rosengren, Lennart Landin, Carl Johan Tiderius, Magnus K. Karlsson   +4 more
doaj   +1 more source

Effects of Teriparatide, Alendronate, or Both in Women with Postmenopausal Osteoporosis [PDF]

, 2010
Joel S. Finkelstein, Jason J. Wyland, Hang Lee, Robert M. Neer   +3 more
openalex   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, EarlyView.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source

Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation‐induced osteoporosis [PDF]

, 2017
Abhishek Chandra, Luqiang Wang, Tiffany Young, Leilei Zhong, Wei‐Ju Tseng, Michael A. Levine, Keith A. Cengel, X. Sherry Liu, Yejia Zhang, Robert J. Pignolo, Ling Qin   +10 more
openalex   +1 more source