Results 61 to 70 of about 427,163 (354)
Romosozumab for the treatment of osteoporosis
Osteoporosis and Sarcopenia, 2018 Romosozumab, a specific inhibitor of sclerostin, is a unique approach to therapy for postmenopausal osteoporosis and related disorders. The elucidation of sclerostin deficiency as the molecular defect of syndromes of high bone mass with normal quality ...
Michael R. McClung
doaj +1 more source
Daily School Physical Activity Improves Academic Performance
Sports, 2020 Physical activity (PA) may improve brain development, cognition, concentration and academic performance. In this prospective controlled intervention study, we increased the level of PA in 338 children aged 6–8 years at study start, from the Swedish ...
Jesper Fritz +4 more
doaj +1 more source
Time trends in pediatric hand fracture incidence in Malmö, Sweden, 1950–2016
Journal of Orthopaedic Surgery and Research, 2021 Background The hand is the second most fractured region in children. It is therefore important to update fracture epidemiology to be able to identify time trends for adequate health care planning. This study reports pediatric hand fracture incidence 2014–
Erika Bergman +4 more
doaj +1 more source
Diagnosis of Osteoporosis by Quantifying Volumetric Bone Mineral Density of Lumbar Vertebrae Using Abdominal CT Images and Two-Compartment Model [PDF]
, 2023 Po-Chieh Hsu +3 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis +19 more
wiley +1 more source
Harnessing Advances in Bone Tissue Engineering for Design of Bone‐on‐Chip Systems
Advanced Healthcare Materials, EarlyView.Bone‐on‐chip (BoC) systems demonstrate significant potential as next‐generation models to study human (patho)physiology and evaluate new therapies. However, progress toward functional, human‐like BoCs has been hindered by the structural and functional complexity of bone. This perspective discusses how insights from bone tissue engineering can guide BoC
Farhad Sanaei +6 more
wiley +1 more source
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Osteoporosis International, 2018 SummaryGuidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis.IntroductionThe International Osteoporosis Foundation and European Society for Clinical and Economic ...
J. Kanis +4 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Spherical bioactive glass nanoparticles containing strontium inhibit osteoclast differentiation and activity, but promote osteoblast activity in osteoblast‐osteoclast in vitro co‐culture. The nanoparticles could be used for the treatment of osteoporosis.
Parichart Naruphontjirakul +2 more
wiley +1 more source
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, EarlyView.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
The Clinical Spectrum of Hypophosphatasia in Older Adults
Clinical Case ReportsAlkaline phosphatase (ALP) should be measured in older adults presenting with fragility fractures. Hypophosphatasia (HPP) should be suspected in individuals with hypophosphatasemia (low serum ALP).
Estefania Valdez Navarro +3 more
doaj +1 more source