Results 201 to 210 of about 39,213 (240)

Serum levels of osteoprotegerin and osteoprotegerin polymorphisms in Gaucher disease

British Journal of Haematology, 2006
SummaryBone involvement in Gaucher disease causes disability and reduced quality of life; loss of function and pain are important indications for enzyme replacement therapy. The purpose of this study was to ascertain whether osteoprotegerin (OPG), which decreases osteoclast activity, is indicative of incipient bone involvement by comparing OPG serum ...
Itai, Magal, Ehud, Lebel, Gheona, Altarescu, Menachem, Itzchaki, Bernard, Rudensky, A Joseph, Foldes, Ari, Zimran, Deborah, Elstein   +7 more
openaire   +2 more sources

Osteoprotegerin Deficiency and Juvenile Paget's Disease

New England Journal of Medicine, 2002
Juvenile Paget's disease, an autosomal recessive osteopathy, is characterized by rapidly remodeling woven bone, osteopenia, fractures, and progressive skeletal deformity. The molecular basis is not known. Osteoprotegerin deficiency could explain juvenile Paget's disease because osteoprotegerin suppresses bone turnover by functioning as a decoy receptor
Michael P Whyte
exaly   +5 more sources

Renal Transplantation Decreases Osteoprotegerin Levels

Transplantation Proceedings, 2006
Vascular calcifications are an important risk factor for cardiovascular mortality and morbidity in patients with chronic renal failure. Osteoprotegerin, a soluble decoy receptor for receptor activator NFkB ligand, has emerged as an independent predictive factor of atherosclerosis and vascular calcification in hemodialysis patients.
A S, Bargnoux, A M, Dupuy, V, Garrigue, S, Deleuze, J P, Cristol, G, Mourad   +5 more
openaire   +2 more sources

Osteoprotegerin and Diabetes-Associated Pathologies

Current Molecular Medicine, 2011
Osteoprotegerin (OPG) is a member of the tumour necrosis factor receptor superfamily of cytokines which, in spite of being initially described as a strong anti-resorptive factor, has lately been considered as a possible link between bone and vascular disease.
A M, Blázquez-Medela, J M, López-Novoa, C, Martínez-Salgado   +2 more
openaire   +2 more sources

Osteoprotegerin: regulator, protector and marker

Orvosi Hetilap, 2008
A csontbiológia terén végzett vizsgálatok vezettek a tumornekrózis-faktorok családjába tartozó receptorok, így az osteoprotegerin és a receptor activator of nuclear factor κB (RANK) szerepének tisztázásához a csontátépülés folyamatának szabályozásában.
Taha, El Hadj Othmane, Gábor, Speer, Bertalan, Fekete, Tamás, Szabó, József, Egresits, Erzsébet, Fodor, István, Kiss, János, Nemcsik, András, Szabó, Zsófia, Németh, Miklós, Szathmári, András, Tislér   +11 more
openaire   +2 more sources

Role for osteoprotegerin in rheumatoid inflammation

Joint Bone Spine, 2004
Osteoprotegerin (OPG), a member of the TNF-receptor family expressed by osteoblasts, has documented effects on the regulation of bone metabolism. OPG inhibits bone resorption and binds with strong affinity to its ligand RANKL, thereby preventing RANKL from binding to its receptor RANK. This system is regulated by calcium-modifying hormones.
Nathalie, Saidenberg-Kermanac'h, Martine, Cohen-Solal, Natacha, Bessis, Marie-Christine, De Vernejoul, Marie-Christophe, Boissier   +4 more
openaire   +2 more sources

Osteoprotegerin and inflammation.

European cytokine network, 2003
RANK, RANKL, and OPG have well established regulatory effects on bone metabolism. RANK is expressed at very high levels on osteoclastic precursors and on mature osteoclasts, and is required for differentiation and activation of the osteoclast. The ligand, RANKL binds to its receptor RANK to induce bone resorption.
N, Saidenberg Kermanac'h, Natacha, Bessis, M, Cohen-Solal, M C, De Vernejoul, Marie-Christophe, Boissier   +4 more
openaire   +1 more source

Osteoprotegerin mitigates tail suspension-induced osteopenia

Bone, 2000
Osteoprotegerin (OPG) is a recently discovered protein related to the tumor necrosis factor receptor family. It has been shown to inhibit ovariectomy (ovx)-induced resorption in rats and increase bone mineral density in young mice. Tail suspension is a procedure that inhibits bone formation in maturing rodents. This study was designed to quantify OPG's
T A, Bateman, C R, Dunstan, V L, Ferguson, D L, Lacey, R A, Ayers, S J, Simske   +5 more
openaire   +2 more sources

Dietary Calcium and Osteoprotegerin

2015
Calcium is an essential trace element of human body. It is both the constructor and regulator of the body, and the source of our human life. Osteoprotegerin (OPG) is a glycoprotein involved in bone metabolism and plays a regulatory role in the immune, the skeletal and the circulatory systems.
Dianjun Sun, Jun Yu, Yanhui Gao, Yuanyuan Li   +3 more
openaire   +1 more source

Heritability of serum osteoprotegerin.

Annals of human genetics, 2011
Serum osteoprotegerin (OPG) level is a key biomarker for numerous traits of clinical importance like diabetes, coronary artery disease, blood pressure, lipid profile, and cancers, but its genetic basis remains poorly understood. We estimated the heritability (h(2)) of serum OPG level in 1442 southern Chinese subjects from 306 families.
Johnny S H, Kwan, Sumei, Xiao, Cora, Bow, Ching-Lung, Cheung, Cissy, Soong, Kam S, Lau, Pak C, Sham, Annie W C, Kung   +7 more
openaire   +4 more sources