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Osteoprotegerin: regulator, protector and marker [PDF]

Orvosi Hetilap, 2008
A csontbiológia terén végzett vizsgálatok vezettek a tumornekrózis-faktorok családjába tartozó receptorok, így az osteoprotegerin és a receptor activator of nuclear factor κB (RANK) szerepének tisztázásához a csontátépülés folyamatának szabályozásában.
Taha, El Hadj Othmane, Gábor, Speer, Bertalan, Fekete, Tamás, Szabó, József, Egresits, Erzsébet, Fodor, István, Kiss, János, Nemcsik, András, Szabó, Zsófia, Németh, Miklós, Szathmári, András, Tislér   +11 more
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Osteoprotegerin as a marker of atherosclerosis: A systematic update

Scandinavian Cardiovascular Journal, 2012
Osteoprotegerin (OPG) may be involved in development of atherosclerosis. To evaluate plasma concentrations of OPG in individuals with stable coronary artery disease (CAD), acute coronary syndrome (ACS), peripheral artery disease (PAD), and cerebrovascular disease (CBVD) a systematic literature review was performed.Studies investigating OPG ...
Lars Melholt Rasmussen, Hans Mickley, Axel Cosmus Pyndt Diederichsen   +2 more
exaly   +3 more sources

The effect of osteoprotegerin nanocomplex on osteoprotegerin and arteriosclerosis in mice

Materials Express, 2023
Osteoprotegerin (OPG), as one of the tumor necrosis factor receptors, is believed to be related with Osteoprotegerin (OP) and arteriosclerosis (AS). This study aims to explore the effect of OPG on osteoblasts (OB) and AS. The nanocomplex Poly(ethylene glycol)-Poly(L-Lysine)-Osteoprotegerin (PPO) was prepared by introducing OPG plasmid to Poly(ethylene ...
Zhiwen He, Shuang Wang, Xiaoxuan Xia
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Osteoprotegerin

Ortopedia, traumatologia, rehabilitacja, 2012
In 1997, a glycoprotein was isolated that blocked osteoclast differentiation from precursor cells. This protein prevented osteoporosis when administered to ovariectomized rats, and led to osteopetrosis when overexpressed. This newly discovered protein was named osteoprotegerin (OPG).
Marleen A. Baak, Bernard Gutin, Kim A. Krawczewski Carhuatanta, Stephen C. Woods, Heinz W. Harbach, Megan M. Wenner, Nina S. Stachenfeld, Timothy M. Griffin, Romain Meeusen, Kevin Pauw, Axel Urhausen, Li Li Ji, David C. Poole, Steven W. Copp, Daniel M. Hirai, Timothy I. Musch   +15 more
openaire   +3 more sources

High osteoprotegerin is associated with development of foot ulcer in type 1 diabetes [PDF]

Journal of Diabetes and Its Complications, 2016
BACKGROUND AND AIM: The bone-related peptide osteoprotegerin has been linked to vascular calcification and peripheral vascular disease. We investigated the association between osteoprotegerin and development of foot complications in persons with type 1 ...
Lars Melholt Rasmussen, Bernt Johan von Scholten, Peter Rossing   +2 more
exaly   +2 more sources

Serum levels of osteoprotegerin and osteoprotegerin polymorphisms in Gaucher disease

British Journal of Haematology, 2006
SummaryBone involvement in Gaucher disease causes disability and reduced quality of life; loss of function and pain are important indications for enzyme replacement therapy. The purpose of this study was to ascertain whether osteoprotegerin (OPG), which decreases osteoclast activity, is indicative of incipient bone involvement by comparing OPG serum ...
Itai, Magal, Ehud, Lebel, Gheona, Altarescu, Menachem, Itzchaki, Bernard, Rudensky, A Joseph, Foldes, Ari, Zimran, Deborah, Elstein   +7 more
openaire   +2 more sources

Osteoprotegerin and Diabetic Macroangiopathy

Hormone and Metabolic Research, 2005
Osteoprotegerin (OPG) is a bone-related protein that is also present in the vasculature. Recent data suggest that it may play a special role in arterial disease among patients with diabetes. Diabetic macroangiopathy is characterized by a series of diffuse, non-atherosclerotic alterations that hypothetically increase the vulnerability of the vessel wall
L M, Rasmussen, T, Ledet
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Osteoprotegerin and kidney disease

Journal of Nephrology, 2014
Vascular calcification in chronic kidney disease (CKD) patients is associated to increased mortality. Osteoprotegerin (OPG) is a soluble tumor necrosis factor (TNF) superfamily receptor that inhibits the actions of the cytokines receptor activator of nuclear factor kappa-B ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL) by preventing ...
Alejandra, Montañez-Barragán, Isaias, Gómez-Barrera, Maria D, Sanchez-Niño, Alvaro C, Ucero, Liliana, González-Espinoza, Alberto, Ortiz   +5 more
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Osteoprotegerin concentration is associated with the presence and severity of peripheral arterial disease in type 2 diabetes mellitus [PDF]

Vasa - European Journal of Vascular Medicine, 2018
. Background: Osteoprotegerin plays a role in the development of several bone diseases. In addition, osteoprotegerin may contribute to the development of vascular disease. Little is known about the association between serum osteoprotegerin levels and the
Ivan Tkáč, Katarina Tokarčíková, Martin Javorský   +2 more
exaly   +2 more sources

Role for osteoprotegerin in rheumatoid inflammation

Joint Bone Spine, 2004
Osteoprotegerin (OPG), a member of the TNF-receptor family expressed by osteoblasts, has documented effects on the regulation of bone metabolism. OPG inhibits bone resorption and binds with strong affinity to its ligand RANKL, thereby preventing RANKL from binding to its receptor RANK. This system is regulated by calcium-modifying hormones.
Nathalie, Saidenberg-Kermanac'h, Martine, Cohen-Solal, Natacha, Bessis, Marie-Christine, De Vernejoul, Marie-Christophe, Boissier   +4 more
openaire   +2 more sources