Results 121 to 130 of about 126,889 (304)
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Primary Cervical Spinal Osteosarcoma Invading the Ligamentum Flavum: Case Report [PDF]
, 2017 Primary cervical spinal osteosarcomas are rare pathologies which rarely invade ligamentum flavum. Extent of tumoral resection is limited due to complex anatomical structure of the cervical region. For this reason, they have poor prognosis. In this report;
Numan KARAARSLAN +2 more
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Clinical and Prognostic Characteristics in Childhood Osteosarcoma: A Single-Center Experience in Türkiye [PDF]
Objective: In our study, we aimed to share the clinical experiences of our center regarding osteosarcoma cases, the most common primary malignant bone tumor in children and adolescents.
Nurdan Taçyıldız +4 more
core +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Osteosarcoma, a malignant primary bone tumor most commonly diagnosed in children and adolescents, has a poorly understood genetic etiology. Genome-wide association studies (GWAS) and candidate-gene analyses have identified putative risk variants in ...
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Review of mifamurtide in the treatment of patients with osteosarcoma [PDF]
, 2010 Leo Kager1, Ulrike Pötschger2, Stefan Bielack31St. Anna Children’s Hospital, Vienna, Austria; 2Children’s Cancer Research Institute, Vienna, Austria; 3Klinikum Stuttgart, Olgahospital, Pediatrics 5 – Oncology ...
Leo Kager +2 more
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Metabolomic investigation of cisplatin‐induced acute kidney injury in paediatric cancer patients
British Journal of Clinical Pharmacology, EarlyView.Aim Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation.
Yong Jin Lim +37 more
wiley +1 more source
, 1944 I El Prof. Luque presenta la historia clínica, con dos ilustraciones, de un joven con un tumor localizado en la región intervértebro-escapular derecha.
Luque, Manuel José, Manuel José Luque
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BMEMat, EarlyView.Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao +4 more
wiley +1 more source
Targeting the mitochondrial protein YME1L to inhibit osteosarcoma cell growth in vitro and in vivo
Cell Death and DiseaseExploring novel diagnostic and therapeutic biomarkers is extremely important for osteosarcoma. YME1 Like 1 ATPase (YME1L), locating in the mitochondrial inner membrane, is key in regulating mitochondrial plasticity and metabolic activity.
Xu Sun +5 more
doaj +1 more source