Results 231 to 240 of about 241,082 (329)

Saucerneol Inhibits the Growth, Migration, and Invasion of Osteosarcoma Cells In Vitro and Prevents Metastasis‐Associated Osteolysis Ex Vivo

open access: yesMolecular Nutrition &Food Research, EarlyView.
Saucerneol (Sauc) is a phytochemical compound classified as a lignan, derived from Saururus chinensis. The JAK2/STAT3 signaling pathway is the primary target of Sauc in osteosarcoma cells. Sauc disrupts mitochondrial potential and increases reactive oxygen species (ROS), leading to apoptotic cell death.
Hyung‐Mun Yun   +3 more
wiley   +1 more source

PPARγ Agonistic Activity of Mimulone and Diplacone Encapsulated in Liposomes and Cyclodextrin Complexes

open access: yesChemistryOpen, EarlyView.
Encapsulation of the geranylated flavanones mimulone and diplacone in hydroxypropyl‐β‐cyclodextrins (HP‐β‐CDs) and liposomes is evaluated for their peroxisome proliferator‐activated receptor gamma agonistic activity. While liposomes reduce efficacy, HP‐β‐CDs preserve up to 91.5% of mimulone's activity and mitigate diplacone's cytotoxicity, highlighting
Daniela Nykodýmová   +4 more
wiley   +1 more source

An autopsy case of the pelvic osteosarcoma, of which the surgical treatment was rejected by the patient.

open access: bronze, 1984
Shinichi Nakamitsu   +4 more
openalex   +2 more sources

Activation of PI3K and deletion of p53 in keratin 15‐expressing mouse mammary cells induces tumor heterogeneity and plasticity modeling metaplastic breast cancer

open access: yesThe Journal of Pathology, EarlyView.
Abstract Although relatively rare, metaplastic breast cancer responds poorly to traditional therapies compared to other subtypes. Accordingly, there is a need for novel animal models to understand its pathogenesis and plasticity. Since alterations in PIK3CA and TP53 genes are common in metaplastic breast cancer, we generated a mouse model of ...
Khoa A Nguyen   +11 more
wiley   +1 more source

High-dose methotrexate citrovorum factor rescue and VEPA therapy as a post-operative adjuvant chemotherapy for the osteosarcoma of the mandible.

open access: bronze, 1986
Yoshiaki Kayata   +7 more
openalex   +2 more sources

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