Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source
A Systematic Review of Cutaneous Involvement in Metastatic Bone Sarcomas: Insights from 102 Reported Cases. [PDF]
Sideris N, Vakirlis E, Sotiriou E.
europepmc +1 more source
Automodification of N‐terminal serine residues facilitates PARP2 release from DNA
PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar +6 more
wiley +1 more source
Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases. [PDF]
Hwang S +5 more
europepmc +1 more source
Rethinking the role of HIF in hepatocellular carcinoma
Tumor hypoxia is a hallmark of cancer driving disease, in part through activation of hypoxia‐inducible factors (HIFs). While HIF‐1α is classically understood as a hypoxia‐responsive transcription factor, its role under normoxic conditions in cells is less clear.
Niall S. Kenneth +2 more
wiley +1 more source
Assessing the accuracy of 3D assistive technologies for surgical guidance of osteosarcoma resections: a comparative laboratory study of mixed reality, patient-specific instruments and freehand approaches. [PDF]
Caceres-Alban J +4 more
europepmc +1 more source
Ossifying spindled and epithelioid tumour (OSET) can show unusual morphologic features, including minimal or absent peripheral ossification, eosinophil‐rich stroma, increased mitotic activity (≥5 mitotic figures per 10 high‐power fields), and necrosis.
Rayan M Sibira +9 more
wiley +1 more source
Molecular Alterations in Osteosarcomas of the Oral and Maxillofacial Region: A Scoping Review
ABSTRACT Background Given the rarity and aggressive nature of osteosarcomas (OS) in the oral and maxillofacial region, understanding their molecular alterations is essential to improve diagnosis, prognosis, and guide targeted therapies. This study aimed to map molecular alterations associated with oral and maxillofacial OS, providing an overview of the
Iara Vieira Ferreira +6 more
wiley +1 more source

