Results 211 to 220 of about 171,941 (345)

Lactate and Lactylation: What We Know and What We Expect in Tumour Progression

Cell Proliferation, EarlyView.
Lactate and lactylation in cancer cells have been shown to accelerate tumour development in various ways, including stemness generation, metabolic dysregulation, cell death, chemotherapy resistance, and cell cycle disorder. In addition, lactate and lactylation promote angiogenesis and create an immunosuppressive microenvironment, which promotes tumour ...
Qi Zhang, Zhenzhen Han, Youjia Duan
wiley   +1 more source

A novel anoikis-resistance related signature predicts pulmonary metastasis in osteosarcoma

Ying Tian, Hairui Liu, Xinglong Miao, Chuanlei Ji, Fengwei Wang, Guojing Chen, Yajie Lu   +6 more
openalex   +1 more source

Evaluating Fine Needle Aspiration Cytology for Diagnostics of Soft Tissue and Bone Tumours

Cytopathology, EarlyView.
Systematic comparison of needle aspiration cytology and histopathology for 503 tumours in soft tissue and bone showed high concordance (positive predictive value 94%–100%, negative predictive value 83%–89%). In this original study, the authors show that FNAC is a safe and non‐invasive method for diagnosing suspected sarcomas, with the main objective to
Amanda Husu, Sandra Wessman, Karin Wallander, Felix Haglund de Flon   +3 more
wiley   +1 more source

Comparative Evaluation of the Antitumor Effect of Rosmarinic Acid and Nordihydroguaiaretic Acid in Osteosarcoma Cells. [PDF]

ACS Omega
Iano FG, Pessôa AS, Sanches MLR, Tokuhara CC, Caires MSB, Oliveira RC, Ximenes VF.   +6 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Five-layer in-silico validation of the CA9–histone-lactylation–drug-efflux axis in osteosarcoma, with read-level cfDNA fragmentomics as a relapse-monitoring feasibility endpoin

Ke Zeng
openalex   +1 more source

Integrative single-cell and bulk transcriptomics uncovers a lipid metabolism-related lncRNA signature alongside the ELFN1-AS1/LYPLA1 axis driving osteosarcoma progression. [PDF]

Front Immunol
Wei X, Wang Z, Yang Q, Lin F, Chen L.
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Navigating the immunosuppressive abyss: current hurdles and innovative breakthroughs in neoadjuvant immunotherapy for osteosarcoma. [PDF]

Front Immunol
Chen G, Hu M, Li Z, Yang K, Chen B, Xu T.   +5 more
europepmc   +1 more source

Osteosarcoma

Veterinary Quarterly, 1998
openaire   +2 more sources