Results 191 to 200 of about 126,889 (304)

The Pathological Roles of Cationic Amino Acid Transporters (CATs) in Cancer

Cancer Science, EarlyView.
CAT family transporters (SLC7A1–SLC7A4) coordinate arginine allocation within the tumor microenvironment, thereby regulating cancer metabolism, mTORC1 signaling, immune responses, and metastatic progression. Emerging evidence supports context‐dependent roles for SLC7A1–SLC7A3, whereas the physiological and pathological functions of SLC7A4 remain poorly
Thant Thant Myo Oo, Yasuhiro Saito
wiley   +1 more source

CXCL14 promotes osteosarcoma cell migration and invasion by inducing epithelial-to-mesenchymal transition. [PDF]

Int J Med Sci
Hou CH, Hsu ML, Wang CH, Liu JF, Chen PC.   +4 more
europepmc   +1 more source

Repression of ROBO1 Enhances Cisplatin Sensitivity in Hypermethylated Subtype of HPV‐Positive Head and Neck Carcinoma

Cancer Science, EarlyView.
DNA hypermethylation causally correlates with better treatment response of HPV(+) HNSCC, and its chemosensitivity might be enhanced by silencing of methylation target genes. Silencing of ROBO1 enhances, and its overexpression reduces, CDDP chemosensitivity, and epigenetic or ROBO1‐targeted interventions may improve therapeutic outcomes in resistant HPV(
Kenta Saeda, Takuya Nakagawa, Atsushi Okabe, Kazuko Kita, Tomoya Kurokawa, Masaki Fukuyo, Hiroki Ueda, Motoaki Seki, Bahityar Rahmutulla, Syuji Yonekura, Toyoyuki Hanazawa, Atsushi Kaneda   +11 more
wiley   +1 more source

Molecular mechanism of <i>miR-27a-3p</i> targeting <i>FBXW7</i> regulating the malignant behavior of osteosarcoma cells. [PDF]

Transl Cancer Res
Zhang H, Liu R, Liu X, Liang W, Wang W, Wang Y.   +5 more
europepmc   +1 more source

Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling

Cell Proliferation, EarlyView.
BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou, Yun Zhai, Xiaochen Liu, Jiaojiao Shao, Jiani Zhou, Zhaoyang Li, Jiale He, Shuxian Lin, Qi Zhang   +8 more
wiley   +1 more source

Emerging Nanocarrier Strategies for Optimized Drug Delivery in the Treatment of Primary Bone Cancer. [PDF]

Oncol Res
Ngema LM, Adeyemi SA, Choonara YE.
europepmc   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Functional Heterogeneity of Canine Osteosarcoma Cell Lines and Differential Expression of <i>miR-27b-3p</i> and IGF2BP3. [PDF]

Cells
Łukasik EM, Marcinkowska KA, Śmieszek A.   +2 more
europepmc   +1 more source

Osteosarcoma

Veterinary Quarterly, 1998
openaire   +2 more sources

Superficial Ewing Sarcoma of the Rectum: A Case Report and the Utility of Molecular Diagnostics

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Ewing sarcoma is an undifferentiated small round cell sarcoma that most commonly presents as a malignant bone tumor in pediatric and young adult patients. The diagnosis is typically confirmed by molecular genetic identification of a fusion protein, most commonly involving members of the FET and ETS gene families.
Jessica L. Muldoon, Laura M. Warmke, Ahmed K. Alomari, Rachel P. Kowal   +3 more
wiley   +1 more source