Results 171 to 180 of about 126,889 (304)

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Lenvatinib induces ferroptosis-related changes in osteosarcoma cells involving the p-STAT3/p53/xCT axis. [PDF]

Front Oncol
Yang C, Ma Y, Shen W, Ma X, Liu X, Du S, Ye K.   +6 more
europepmc   +1 more source

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

SMARCAL1 is a new osteosarcoma predisposition gene. [PDF]

J Natl Cancer Inst
Rafati M, Guenther LM, Egolf LE, Gianferante M, Kim J, Wang K, Zhu B, Spector LG, Anderson N, Janeway KA, Barkauskas DA, Hawkins DS, Patiño-Garcia A, Lupo PJ, Scheurer ME, Morton L, Armstrong GT, Sapkota Y, Gramatges MM, Serra M, Hattinger C, Scotlandi K, Andrulis IL, Wunder JS, Ballinger ML, Thomas DM, Yeager M, Dean M, Stewart DR, Vogt A, Liu J, Hicks BD, Huang WY, Landi MT, Lori A, Diver WR, Savage SA, Chanock SJ, Mirabello L.   +38 more
europepmc   +1 more source

Prospective comparison of chronic pain and quality of life in dogs presenting with five common orthopaedic conditions

Veterinary Record, EarlyView.
Abstract Background Chronic pain, which affects multiple aspects of dogs' wellbeing, including quality of life (QoL), was assessed in dogs with elbow dysplasia, hip dysplasia, medial patella luxation, cranial cruciate ligament rupture or osteoarthritis.
Christos Dorlis, Dylan N. Clements, John M. Ryan   +2 more
wiley   +1 more source

Osteosarcoma in the Setting of Genetically Confirmed <i>IFITM5-</i>Related Osteogenesis Imperfecta. [PDF]

Case Rep Pathol
McKane A, Noel M, Hiatt A, Emory C.
europepmc   +1 more source

Osteosarcoma of the Breast

Journal of Breast Imaging, 2020
Dogan S Polat, Basak E Dogan
openaire   +2 more sources

Matrix Viscoelasticity: The Overlooked Architect of Solid Tumour Evolution

Organ Medicine, EarlyView.
Ruixi Huang, Yupeng Guan
wiley   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Paget's Disease of the Spine as a Catalyst for Osteosarcoma: A Narrative Review. [PDF]

Cureus
Del Rio Montesinos GF, Yoon K, Ayano A, Lee L, Ehioghae M, Japa JP, Benn LA, Mesfin A.   +7 more
europepmc   +1 more source