Results 161 to 170 of about 171,941 (345)

Integrated multi-omics profiling identifies ECM-associated and systemic metabolic alterations associated with osteosarcoma metastasis [PDF]

Ning Liu, Juan Wang, Yan Lai, Zhen Wu, Canhua Xu, Qin Chen, Cheng Yang   +6 more
openalex   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Endobronchial Extension of Metastatic Osteosarcoma Causing Central Airway Obstruction: A Case Report. [PDF]

Case Rep Surg
Dasgupta M, Woodall J, Brinkley W, Glenn C, Probst C, Branca P, Bevill B, Jordan S.   +7 more
europepmc   +1 more source

Bone [PDF]

Osteosarcoma, a malignant primary bone tumor most commonly diagnosed in children and adolescents, has a poorly understood genetic etiology. Genome-wide association studies (GWAS) and candidate-gene analyses have identified putative risk variants in ...

core  

A single‐molecule prodrug synergistically suppresses MYC‐amplified osteosarcoma through sequential nitric oxide release and photodynamic therapy

Smart Molecules, EarlyView.
A cascade‐responsive small‐molecule prodrug (DHU‐NO3) sequentially releases methylene blue (triggered by reactive oxygen species) and nitric oxide (controlled by 405 nm light), enabling precise spatiotemporal coordination of photodynamic therapy and NO gas therapy to effectively inhibit MYC‐amplified osteosarcoma growth.
Shuxin Peng, Jiangpeng Wu, Shasha Wang, Ying Gao, Xuran Guo, Mengpan Li, Youjin Wu, Yun Wang, Zhengdong Cai, Yingqi Hua, Peng Wei, Yinghua Gao, Tao Yi   +12 more
wiley   +1 more source

TMCC2 suppresses osteosarcoma growth and is associated with M1-like macrophage polarization

Yebing Zhang, Long Zhang, Sihua Zheng, Chenwei Guan, Xuezheng Zhao   +4 more
openalex   +1 more source

Exosomal CircRNA_102619-miR-330-3p Interaction Regulates Osteosarcoma Progression and Metastasis by Forming the Lung Pre-Metastatic Niche. [PDF]

Int J Mol Sci
Lien MY, Chang YH, Tsai HC, Hsu CJ, Liu CL, Guo JH, Ho TY, Lin LW, Fong YC, Tang CH.   +9 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Prospective comparison of chronic pain and quality of life in dogs presenting with five common orthopaedic conditions

Veterinary Record, EarlyView.
Abstract Background Chronic pain, which affects multiple aspects of dogs' wellbeing, including quality of life (QoL), was assessed in dogs with elbow dysplasia, hip dysplasia, medial patella luxation, cranial cruciate ligament rupture or osteoarthritis.
Christos Dorlis, Dylan N. Clements, John M. Ryan   +2 more
wiley   +1 more source

Absence of a reproducible survival association for a ferroptosis-senescence intersection program in osteosarcoma: retrospective methodological audit trail

Dong Zhang
openalex   +1 more source