Results 31 to 40 of about 171,941 (345)

LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway

Journal of Orthopaedic Surgery and Research, 2022
Background Osteosarcoma is highly malignant. The migration, invasion, and chemoresistance contribute to poor prognosis of osteosarcoma. Research reported that endogenous bornavirus-like nucleoprotein 3 pseudogene (EBLN3P) promotes the progression of ...
Ming-Xia Sun, Hai-Yan An, Yan-Bin Sun, Yan-bao Sun, Bing Bai   +4 more
doaj   +1 more source

ROCK2 Regulates Invasion and Migration of Osteosarcoma Cells

Zhongliu Fangzhi Yanjiu, 2022
Objective To analyze the expression of ROCK2 in osteosarcoma tissues and explore its effect on the invasion and migration of osteosarcoma cells and related mechanism.
SHAN Wenhao, YI Weijiang, ZHANG Sijun, JIANG Wei, XIA Jian   +4 more
doaj   +1 more source

Interleukin-24 inhibits the phenotype and tumorigenicity of cancer stem cell in osteosarcoma via downregulation Notch and Wnt/β-catenin signaling

Journal of Bone Oncology, 2021
Osteosarcoma frequently presents as recurrence and metastasis, even if the primary lesion was eradicated and/or radiotherapy and chemotherapy were administered.
Baobiao Zhuo, Xihua Wang, Yang Shen, Jiayong Li, Shixian Li, Yuan Li, Rong Wang   +6 more
doaj   +1 more source

Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy

Journal of Orthopaedic Surgery and Research, 2023
Background Osteosarcoma is a common malignant bone tumor, and chemotherapy can effectively improve the prognosis. MicroRNA-331 (MiR-331) is associated with poor cancer outcomes. However, the role of miR-331 in osteosarcoma remains to be explored. Methods
Chenyang Meng, Yun Yang, Wei Feng, Penglei Ma, Rui Bai   +4 more
doaj   +1 more source

Cordycepin augments the chemosensitivity of osteosarcoma to cisplatin by activating AMPK and suppressing the AKT signaling pathway

Cancer Cell International, 2021
Background Osteosarcoma is the most common primary bone tumor in children and adolescents. However, some patients with osteosarcoma develop resistance to chemotherapy, leading to a poor clinical prognosis.
Hong-Bo Li, Jun-Kai Chen, Ze-Xin Su, Qing-Lin Jin, Li-Wen Deng, Gang Huang, Jing-Nan Shen   +6 more
doaj   +1 more source

Osteosarcoma has not become attention to society profile of osteosarcoma patients at dr. soetomo general hospital surabaya “a retrospective study” [PDF]

, 2018
Background: Osteosarcoma is the most common bone neoplasm found in the community but evaluation osteosarcoma cases in RSUD Dr. Soetomo has not been updated since 1995.
Yesa Suwandani, Muhammad Hardian Basuki, Ferdiansyah Mahyudin, NIDN. 8890010016, Yunus Abdul Bari, Mouli Edward   +4 more
core   +1 more source

MicroRNA-448 suppresses osteosarcoma cell proliferation and invasion through targeting EPHA7. [PDF]

PLoS ONE, 2017
Osteosarcoma is the most common type of malignant bone tumor, often affecting adolescents and children. MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in osteosarcoma tumorigenesis.
Xiangkun Wu, Lihua Yan, Yongxi Liu, Wenfeng Xian, Liuyu Wang, Xunmeng Ding   +5 more
doaj   +1 more source

Fibroblastic growth factor receptor 1 amplification in osteosarcoma is associated with poor response to neo-adjuvant chemotherapy. [PDF]

, 2014
Osteosarcoma, the most common primary bone sarcoma, is a genetically complex disease with no widely accepted biomarker to allow stratification of patients for treatment.
M. Fernanda Amary, Behjati, S., Ye, H., Berisha, F, Strauss, S.J., Lehovsky, K., Campbell, P.J., Frezza, A.M., Presneau, Nadège, Pillay, N., Fernanda Amary, M., Bhavisha Khatri, Tarpey, P, Tarpey, P., Pillay, N, Adrienne M. Flanagan, Sam Behjati, Fernanda Amary, M, Tirabosco, R, Patrick Tarpey, Tirabosco, R., Peter J. Campbell, Roberto Tirabosco, Presneau, N, Nischalan Pillay, Khatri, B., Georgina Forbes, Frezza, AM, Flanagan, AM, Fitim Berisha, Anna M. Frezza, Campbell, PJ, Nadège Presneau, Strauss, SJ, Lehovsky, K, Khatri, B, Forbes, G., Sandra J. Strauss, Forbes, G, Behjati, S, Hongtao Ye, Berisha, F., Flanagan, A.M., Ye, H, Katie Lehovsky   +44 more
core   +1 more source

Cellular functions and molecular mechanisms of ubiquitination in osteosarcoma

Frontiers in Oncology, 2022
Although some advances have been made in the treatment of osteosarcoma in recent years, surgical resection remains the mainstream treatment. Initial and early diagnosis of osteosarcoma could be very difficult to achieve due to the insufficient ...
Jiaxun Song, Xiaofeng Yuan, Lianhua Piao, Jiawen Wang, Pu Wang, Ming Zhuang, Jie Liu, Zhiwei Liu, Zhiwei Liu   +8 more
doaj   +1 more source

OSTEOSARCOMA IN THE PEDIATRIC AGE

, 2018
Osteosarcoma is the most common form of malignant bone tumor; it is characterized by malignant mesenchymal cells producing osteoid or immature bone. The tumor predominantly involves children, teenagers and young adults with a peak of incidence in the ...
Francesco Roberto Evola
core   +1 more source