Results 31 to 40 of about 126,889 (304)

DEPDC1 as a crucial factor in the progression of human osteosarcoma

Cancer Medicine, 2023
Objective Novel therapeutic strategies are emerging with the increased understanding of the underlying mechanisms of human osteosarcoma. This current study tends to decipher the potentially critical role of DEP domain‐containing 1 (DEPDC1), a tumor ...
Lin Shen, Han Li, Ronghan Liu, Chendan Zhou, Morgan Bretches, Xuan Gong, Laitong Lu, Ying Zhang, Kai Zhao, Bin Ning, Shang‐You Yang, Aijun Zhang   +11 more
doaj   +1 more source

SLC7A8 coding for LAT2 is associated with early disease progression in osteosarcoma and transports doxorubicin [PDF]

, 2022
Background: Despite (neo)adjuvant chemotherapy with cisplatin, doxorubicin and methotrexate, some patients with primary osteosarcoma progress during first-line systemic treatment and have a poor prognosis.
Hagleitner, dr. M.M. (Radboud University) DAI=info:eu-repo/dai/nl/321543564, Nijhoff, G., Vos, MSc. H.I. (Radboud University) DAI=info:eu-repo/dai/nl/397117477, Loo, dr. D.M.W.M. te (Radboud University) DAI=info:eu-repo/dai/nl/235246840, Schreuder, prof. dr. H.W.B. (Radboud University) DAI=info:eu-repo/dai/nl/16403093X, Koenderink, dr. ir. J.B. (Radboud University) DAI=info:eu-repo/dai/nl/217400426, Patiño-García, A., Bont, prof. dr. E.S.J.M. de, Versleijen-Jonkers, dr. Y.M.H. (Radboud University) DAI=info:eu-repo/dai/nl/297696270, Touw, D.J., González-Neira, A., Windsor, R., Coenen, dr. M.J.H. (Radboud University) DAI=info:eu-repo/dai/nl/27403364X, Flucke, dr. U.E. (Radboud University) DAI=info:eu-repo/dai/nl/314442022, Catchpoole, D., Hurkmans, E.G.E. (Radboud University) DAI=info:eu-repo/dai/nl/426286413, Graaf, prof. dr. W.T.A. van der (Radboud University) DAI=info:eu-repo/dai/nl/113100892, Roeffen, M.H.S. (Radboud University) DAI=info:eu-repo/dai/nl/321594657, Groothuismink, ing. J.M. (Radboud University) DAI=info:eu-repo/dai/nl/426286189, Nagabushan, S., Saletta, F., Heuvel, ing. J.M.W. van den (Radboud University) DAI=info:eu-repo/dai/nl/314445242, Muradjan, G., Brunner, prof. dr. H.G. (Radboud University) DAI=info:eu-repo/dai/nl/112228682, Kremer, L.C.M., Guchelaar, H.J., McCowage, G., Caron, H.N., Cleton-Jansen, A.M., Gelderblom, A.J.   +29 more
core   +1 more source

LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway

Journal of Orthopaedic Surgery and Research, 2022
Background Osteosarcoma is highly malignant. The migration, invasion, and chemoresistance contribute to poor prognosis of osteosarcoma. Research reported that endogenous bornavirus-like nucleoprotein 3 pseudogene (EBLN3P) promotes the progression of ...
Ming-Xia Sun, Hai-Yan An, Yan-Bin Sun, Yan-bao Sun, Bing Bai   +4 more
doaj   +1 more source

ROCK2 Regulates Invasion and Migration of Osteosarcoma Cells

Zhongliu Fangzhi Yanjiu, 2022
Objective To analyze the expression of ROCK2 in osteosarcoma tissues and explore its effect on the invasion and migration of osteosarcoma cells and related mechanism.
SHAN Wenhao, YI Weijiang, ZHANG Sijun, JIANG Wei, XIA Jian   +4 more
doaj   +1 more source

Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma [PDF]

, 2023
Hongliang Wu,1– 3 Sihang Zheng,4 Qun He,5 Yan Li3 1Department of Orthopedics, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China; 2Department of Orthopedics, Fuzhou Second Hospital ...
Li Y, Zheng S, He Q, Wu H
core  

Interleukin-24 inhibits the phenotype and tumorigenicity of cancer stem cell in osteosarcoma via downregulation Notch and Wnt/β-catenin signaling

Journal of Bone Oncology, 2021
Osteosarcoma frequently presents as recurrence and metastasis, even if the primary lesion was eradicated and/or radiotherapy and chemotherapy were administered.
Baobiao Zhuo, Xihua Wang, Yang Shen, Jiayong Li, Shixian Li, Yuan Li, Rong Wang   +6 more
doaj   +1 more source

In vitro studies on MG63 osteosarcoma cells: mitochondrial phenotype differences in doxorubicin resistance [PDF]

, 2022
reservedLa doxorubicina è un farmaco chemioterapico impiegato per il trattamento di diversi tumori solidi tra cui l’osteosarcoma. Nonostante la comprovata efficacia clinica di questo farmaco, il suo utilizzo rimane problematico sia per la severita ...
GANARIN, ALEXIA
core  

Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy

Journal of Orthopaedic Surgery and Research, 2023
Background Osteosarcoma is a common malignant bone tumor, and chemotherapy can effectively improve the prognosis. MicroRNA-331 (MiR-331) is associated with poor cancer outcomes. However, the role of miR-331 in osteosarcoma remains to be explored. Methods
Chenyang Meng, Yun Yang, Wei Feng, Penglei Ma, Rui Bai   +4 more
doaj   +1 more source

Cordycepin augments the chemosensitivity of osteosarcoma to cisplatin by activating AMPK and suppressing the AKT signaling pathway

Cancer Cell International, 2021
Background Osteosarcoma is the most common primary bone tumor in children and adolescents. However, some patients with osteosarcoma develop resistance to chemotherapy, leading to a poor clinical prognosis.
Hong-Bo Li, Jun-Kai Chen, Ze-Xin Su, Qing-Lin Jin, Li-Wen Deng, Gang Huang, Jing-Nan Shen   +6 more
doaj   +1 more source

MicroRNA-448 suppresses osteosarcoma cell proliferation and invasion through targeting EPHA7. [PDF]

PLoS ONE, 2017
Osteosarcoma is the most common type of malignant bone tumor, often affecting adolescents and children. MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in osteosarcoma tumorigenesis.
Xiangkun Wu, Lihua Yan, Yongxi Liu, Wenfeng Xian, Liuyu Wang, Xunmeng Ding   +5 more
doaj   +1 more source