Results 21 to 30 of about 181,577 (204)

Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis

Journal of Translational Medicine, 2021
Background Osteosarcoma is a common type of bone tumors and frequently occurs in children and adolescents. Cancer stem cells (CSCs) are a unique sub-type of self-renewal cancer cells and the stemness of cancer cells are involved in the spread, recurrence,
Pengxu Shi, Yueting Li, Qingsheng Guo
doaj   +1 more source

Evaluation of Weight Change During Carboplatin Therapy in Dogs With Appendicular Osteosarcoma. [PDF]

, 2017
BackgroundThe prevalence of cancer cachexia in veterinary medicine has not been studied widely, and as of yet, no definitive diagnostic criteria effectively assess this syndrome in veterinary patients.Objectives(1) To determine the patterns of weight ...
Boston, SE, Culp, WTN, Kilkenny, JJ, Lu, X, Singh, A, Skorupski, KA, Story, AL, Woods, JP   +7 more
core   +1 more source

The nuclear-cytoplasmic trafficking of a chromatin-modifyng and remodelling protein (KMT2C), in osteosarcoma [PDF]

, 2018
Osteosarcoma is the most common paediatric primary non-hematopoietic bone tumor; the survival is related to the response to chemotherapy and development of metastases.
Carletti, Raffaella, Chiappetta, Caterina, Della Rocca, Carlo, Di Cristofano, Claudio, Petrozza, Vincenzo, Puggioni, Chiara   +5 more
core   +1 more source

Cullin-1 Regulates MG63 Cell Proliferation and Metastasis and is a Novel Prognostic Marker of Osteosarcoma

The International Journal of Biological Markers, 2017
Background There is no reliable marker available for early detection, diagnostic confirmation or disease prognosis of osteosarcoma. Cullin-1 (CUL1) is a newly reported tumor-related gene, and we aimed to unravel its role in osteosarcoma.
Qinghua Cheng, Guoyong Yin
doaj   +1 more source

DEPDC1 as a crucial factor in the progression of human osteosarcoma

Cancer Medicine, 2023
Objective Novel therapeutic strategies are emerging with the increased understanding of the underlying mechanisms of human osteosarcoma. This current study tends to decipher the potentially critical role of DEP domain‐containing 1 (DEPDC1), a tumor ...
Lin Shen, Han Li, Ronghan Liu, Chendan Zhou, Morgan Bretches, Xuan Gong, Laitong Lu, Ying Zhang, Kai Zhao, Bin Ning, Shang‐You Yang, Aijun Zhang   +11 more
doaj   +1 more source

Decreased expression of miR-195 mediated by hypermethylation promotes osteosarcoma

Open Medicine, 2022
Osteosarcoma (OS) is the most common type of primary malignant bone tumor. The early lung metastasis of osteosarcoma is one of the main factors of poor prognosis.
Sun Tianhao, Liu Dongning, Wu Jun, Lu William W., Zhao Xiaoli, Wong Tak Man, Liu Zhi-Li   +6 more
doaj   +1 more source

Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy

Journal of Orthopaedic Surgery and Research, 2023
Background Osteosarcoma is a common malignant bone tumor, and chemotherapy can effectively improve the prognosis. MicroRNA-331 (MiR-331) is associated with poor cancer outcomes. However, the role of miR-331 in osteosarcoma remains to be explored. Methods
Chenyang Meng, Yun Yang, Wei Feng, Penglei Ma, Rui Bai   +4 more
doaj   +1 more source

ROCK2 Regulates Invasion and Migration of Osteosarcoma Cells

Zhongliu Fangzhi Yanjiu, 2022
Objective To analyze the expression of ROCK2 in osteosarcoma tissues and explore its effect on the invasion and migration of osteosarcoma cells and related mechanism.
SHAN Wenhao, YI Weijiang, ZHANG Sijun, JIANG Wei, XIA Jian   +4 more
doaj   +1 more source

Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models. [PDF]

, 2017
Metastasis is a major cause of mortality for cancer patients and remains as the greatest challenge in cancer therapy. Driven by multiple factors, metastasis may not be controlled by the inhibition of single target.
DeVere White, Ralph W, Duan, Zhijian, Ho, Pui Yan, Jian, Chao, Lam, Kit S, Lara, Primo N, Qiu, Jing-Xin, Tu, Mei-Juan, Wun, Theodore, Yu, Ai-Ming, Yu, Ai-Xi, Zhang, Qianyu   +11 more
core   +1 more source

Cordycepin augments the chemosensitivity of osteosarcoma to cisplatin by activating AMPK and suppressing the AKT signaling pathway

Cancer Cell International, 2021
Background Osteosarcoma is the most common primary bone tumor in children and adolescents. However, some patients with osteosarcoma develop resistance to chemotherapy, leading to a poor clinical prognosis.
Hong-Bo Li, Jun-Kai Chen, Ze-Xin Su, Qing-Lin Jin, Li-Wen Deng, Gang Huang, Jing-Nan Shen   +6 more
doaj   +1 more source