Results 11 to 20 of about 171,941 (345)
European Journal of Cancer, 1997 Over the last several decades, significant advances have been made in our ability to understand and treat osteosarcoma. In this article we describe the diagnosis, evaluation, and treatment of patients with this disease. The surgical issues are discussed. We review the major clinical trials that have led to our current level of understanding.
J S, Dome, C L, Schwartz
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Journal of the American Academy of Orthopaedic Surgeons, 2009 Osteosarcoma, the most common bone sarcoma, affects approximately 560 children and adolescents annually in the United States. The incidence of new diagnoses peaks in the second decade of life. Twenty percent of patients present with clinically detectable metastases, with micrometastases presumed to be present in many of the remaining patients ...
Patrick J, Messerschmitt +4 more
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, 2009 Studies to determine the etiology of osteosarcoma involve epidemiologic and environmental factors and genetic impairments. Factors related to patient characteristics include age, gender, ethnicity, growth and height, genetic and familial factors, and preexisting bone abnormalities.
G. Ottaviani, N. Jaffe
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miR-26a Reverses Multidrug Resistance in Osteosarcoma by Targeting MCL1
Frontiers in Cell and Developmental Biology, 2021 The multidrug resistance (MDR) acquired in human osteosarcoma is a huge obstacle for effective chemotherapy. Recently, microRNA-26a (miR-26a) has been associated with the pathogenesis and progression of osteosarcoma.
Ming Li, Wei Ma
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TMED3/RPS15A Axis promotes the development and progression of osteosarcoma
Cancer Cell International, 2021 Background Osteosarcoma is a primary malignant tumor that mainly affects children and young adults. Transmembrane emp24 trafficking protein 3 (TMED3) may be involved in the regulation of malignant cancer behaviors.
Wei Xu +6 more
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RNA Binding Proteins and Osteosarcoma
, 2023 Osteosarcoma, the most prevalent form of bone cancer, is primarily attributed to the abnormal behavior of bone-forming mesenchymal stem cells and its occurrence as the third most common cancer among children is of concern.
Murphy, J.J. +2 more
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Nature Reviews Disease Primers, 2022 Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in males. The key pathophysiological mechanism involves several possible genetic drivers of disease linked to bone formation, causing malignant progression and metastasis.
Beird, Hannah +9 more
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Indoleamine 2,3- Dioxygenase: A Novel Immunotherapeutic Target for Osteosarcoma [PDF]
, 2022 Introduction: Tumour-emitted molecules induce immunosuppression in the tumour microenvironment. An immunosuppressive enzyme, indoleamine 2,3-dioxygenase (IDO/IDO1), facilitates immune escape in several malignant tumours, including osteosarcoma ...
Farooq, Asim +5 more
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Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis
Journal of Translational Medicine, 2021 Background Osteosarcoma is a common type of bone tumors and frequently occurs in children and adolescents. Cancer stem cells (CSCs) are a unique sub-type of self-renewal cancer cells and the stemness of cancer cells are involved in the spread, recurrence,
Pengxu Shi, Yueting Li, Qingsheng Guo
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CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway
Frontiers in Oncology, 2022 Cell migration inducing protein (CEMIP) has been linked to carcinogenesis in several types of cancers. However, the role and mechanism of CEMIP in osteosarcoma remain unclear. This study investigated the role of CEMIP in the progression and metastasis of
Jun Cheng +9 more
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