Results 11 to 20 of about 134,783 (203)
Nature Reviews Disease Primers, 2022 Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in males. The key pathophysiological mechanism involves several possible genetic drivers of disease linked to bone formation, causing malignant progression and metastasis.
Beird, Hannah +9 more
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SOX12 Promotes Stem Cell-Like Phenotypes and Osteosarcoma Tumor Growth by Upregulating JAGGED1
Stem Cells International, 2021 SOX12 plays a role in promoting the growth of some tumors; however, its role in osteosarcoma remains unclear. From gene expression omnibus (GEO) and tumor alterations relevant for genomics-driven therapy (TARGET) databases, Kaplan–Meier analyses were ...
Weifei Zhang +8 more
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Signal Transduction and Targeted Therapy, 2021 Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Although activator of HSP90 ATPase activity 1 (AHA1) is reported to be a potential oncogene, its role in osteosarcoma progression remains largely unclear ...
Diwei Zheng +13 more
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TMED3/RPS15A Axis promotes the development and progression of osteosarcoma
Cancer Cell International, 2021 Background Osteosarcoma is a primary malignant tumor that mainly affects children and young adults. Transmembrane emp24 trafficking protein 3 (TMED3) may be involved in the regulation of malignant cancer behaviors.
Wei Xu +6 more
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miR-26a Reverses Multidrug Resistance in Osteosarcoma by Targeting MCL1
Frontiers in Cell and Developmental Biology, 2021 The multidrug resistance (MDR) acquired in human osteosarcoma is a huge obstacle for effective chemotherapy. Recently, microRNA-26a (miR-26a) has been associated with the pathogenesis and progression of osteosarcoma.
Ming Li, Wei Ma
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Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis
Journal of Translational Medicine, 2021 Background Osteosarcoma is a common type of bone tumors and frequently occurs in children and adolescents. Cancer stem cells (CSCs) are a unique sub-type of self-renewal cancer cells and the stemness of cancer cells are involved in the spread, recurrence,
Pengxu Shi, Yueting Li, Qingsheng Guo
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CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway
Frontiers in Oncology, 2022 Cell migration inducing protein (CEMIP) has been linked to carcinogenesis in several types of cancers. However, the role and mechanism of CEMIP in osteosarcoma remain unclear. This study investigated the role of CEMIP in the progression and metastasis of
Jun Cheng +9 more
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lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression
Molecular Therapy: Nucleic Acids, 2021 Osteosarcoma is a highly aggressive cancer common in children and adolescents. There is still a lack of effective treatments for metastatic or recurrent osteosarcoma.
Lei Ding +9 more
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Maxillary osteosarcoma in a beef suckler cow [PDF]
, 2012 A ten-year-old beef suckler cow was referred to the Scottish Centre for Production Animal Health and Food Safety of the University of Glasgow, because of facial swelling in the region of the right maxilla.
Prins, D.G.J. +11 more
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RNA Binding Proteins and Osteosarcoma
, 2023 Osteosarcoma, the most prevalent form of bone cancer, is primarily attributed to the abnormal behavior of bone-forming mesenchymal stem cells and its occurrence as the third most common cancer among children is of concern.
Murphy, J.J. +2 more
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