Results 11 to 20 of about 126,889 (304)
SOX12 Promotes Stem Cell-Like Phenotypes and Osteosarcoma Tumor Growth by Upregulating JAGGED1
Stem Cells International, 2021 SOX12 plays a role in promoting the growth of some tumors; however, its role in osteosarcoma remains unclear. From gene expression omnibus (GEO) and tumor alterations relevant for genomics-driven therapy (TARGET) databases, Kaplan–Meier analyses were ...
Weifei Zhang +8 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Although activator of HSP90 ATPase activity 1 (AHA1) is reported to be a potential oncogene, its role in osteosarcoma progression remains largely unclear ...
Diwei Zheng +13 more
doaj +1 more source
Frontiers in Oncology, 2022 Osteosarcoma is a kind of aggressive human malignancy, and the prognosis of the patients with osteosarcoma remains low. Studies have demonstrated that the tumor microenvironment plays a key role in regulating osteosarcoma progression. Recent studies have
Weidong Liu +4 more
doaj +1 more source
miR-26a Reverses Multidrug Resistance in Osteosarcoma by Targeting MCL1
Frontiers in Cell and Developmental Biology, 2021 The multidrug resistance (MDR) acquired in human osteosarcoma is a huge obstacle for effective chemotherapy. Recently, microRNA-26a (miR-26a) has been associated with the pathogenesis and progression of osteosarcoma.
Ming Li, Wei Ma
doaj +1 more source
TMED3/RPS15A Axis promotes the development and progression of osteosarcoma
Cancer Cell International, 2021 Background Osteosarcoma is a primary malignant tumor that mainly affects children and young adults. Transmembrane emp24 trafficking protein 3 (TMED3) may be involved in the regulation of malignant cancer behaviors.
Wei Xu +6 more
doaj +1 more source
Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis
Journal of Translational Medicine, 2021 Background Osteosarcoma is a common type of bone tumors and frequently occurs in children and adolescents. Cancer stem cells (CSCs) are a unique sub-type of self-renewal cancer cells and the stemness of cancer cells are involved in the spread, recurrence,
Pengxu Shi, Yueting Li, Qingsheng Guo
doaj +1 more source
CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway
Frontiers in Oncology, 2022 Cell migration inducing protein (CEMIP) has been linked to carcinogenesis in several types of cancers. However, the role and mechanism of CEMIP in osteosarcoma remain unclear. This study investigated the role of CEMIP in the progression and metastasis of
Jun Cheng +9 more
doaj +1 more source
Indoleamine 2,3- Dioxygenase: A Novel Immunotherapeutic Target for Osteosarcoma [PDF]
, 2022 Introduction: Tumour-emitted molecules induce immunosuppression in the tumour microenvironment. An immunosuppressive enzyme, indoleamine 2,3-dioxygenase (IDO/IDO1), facilitates immune escape in several malignant tumours, including osteosarcoma ...
Farooq, Asim +2 more
core +2 more sources
Maxillary osteosarcoma in a beef suckler cow [PDF]
, 2012 A ten-year-old beef suckler cow was referred to the Scottish Centre for Production Animal Health and Food Safety of the University of Glasgow, because of facial swelling in the region of the right maxilla.
Prins, D.G.J. +11 more
core +1 more source
A Novel Approach to Anti-Cancer Therapy in Osteosarcoma [PDF]
, 2021 In this paper I have sought to outline the molecular pathogenesis of osteosarcoma with some reference to potential therapeutic targets currently under investigation.The genetic basis of osteosarcoma has also been presented and discussed, along with the ...
Kunlere, Michael Ayodeji
core