Results 41 to 50 of about 126,514 (307)

OSTEOSARCOMA IN THE PEDIATRIC AGE

, 2018
Osteosarcoma is the most common form of malignant bone tumor; it is characterized by malignant mesenchymal cells producing osteoid or immature bone. The tumor predominantly involves children, teenagers and young adults with a peak of incidence in the ...
Francesco Roberto Evola
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Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Circulating exosomes secreted by osteosarcoma cells are potential biomarkers for metastasis

, 2021
Selva, Erica M.Sampson, ValerieOsteosarcoma is a primary malignant bone tumor found in children and is the third most common cancer in children and adolescents.
Jeshurin, Madeline
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Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Analysis of the genetic predisposition of patients with osteosarcoma or Ewing's sarcoma to other pathologies

, 2023
reservedLa tesi è volta a studiare e analizzare le mutazioni genetiche di pazienti con osteosarcoma o sarcoma di Ewing per comprendere se i soggetti dello studio siano geneticamente predisposti ad altre patologie.
BIANCHIN, CARLOTTA
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

MicroRNA-448 suppresses osteosarcoma cell proliferation and invasion through targeting EPHA7. [PDF]

PLoS ONE, 2017
Osteosarcoma is the most common type of malignant bone tumor, often affecting adolescents and children. MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in osteosarcoma tumorigenesis.
Xiangkun Wu, Lihua Yan, Yongxi Liu, Wenfeng Xian, Liuyu Wang, Xunmeng Ding   +5 more
doaj   +1 more source

Osteosarcoma associated with diamond-blackfan anaemia: a case of a child receiving growth hormone therapy [PDF]

, 2004
Purpose: Diamond–Blackfan anaemia (DBA) is a rare pure congenital red cell aplasia, usually presenting in infancy or early childhood. The literature suggests a predisposition to haemopoietic malignancy but in addition solid tumours have been reported ...
Briggs, TW, Pringle, J, Lee, RS, Higgs, D, Haddo, O   +4 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

SLC7A8 coding for LAT2 is associated with early disease progression in osteosarcoma and transports doxorubicin

, 2022
Background: Despite (neo)adjuvant chemotherapy with cisplatin, doxorubicin and methotrexate, some patients with primary osteosarcoma progress during first-line systemic treatment and have a poor prognosis.
Hagleitner, dr. M.M. (Radboud University) DAI=info:eu-repo/dai/nl/321543564, Nijhoff, G., Vos, MSc. H.I. (Radboud University) DAI=info:eu-repo/dai/nl/397117477, Loo, dr. D.M.W.M. te (Radboud University) DAI=info:eu-repo/dai/nl/235246840, Schreuder, prof. dr. H.W.B. (Radboud University) DAI=info:eu-repo/dai/nl/16403093X, Koenderink, dr. ir. J.B. (Radboud University) DAI=info:eu-repo/dai/nl/217400426, Patiño-García, A., Bont, prof. dr. E.S.J.M. de, Versleijen-Jonkers, dr. Y.M.H. (Radboud University) DAI=info:eu-repo/dai/nl/297696270, Touw, D.J., González-Neira, A., Windsor, R., Coenen, dr. M.J.H. (Radboud University) DAI=info:eu-repo/dai/nl/27403364X, Flucke, dr. U.E. (Radboud University) DAI=info:eu-repo/dai/nl/314442022, Catchpoole, D., Hurkmans, E.G.E. (Radboud University) DAI=info:eu-repo/dai/nl/426286413, Graaf, prof. dr. W.T.A. van der (Radboud University) DAI=info:eu-repo/dai/nl/113100892, Roeffen, M.H.S. (Radboud University) DAI=info:eu-repo/dai/nl/321594657, Groothuismink, ing. J.M. (Radboud University) DAI=info:eu-repo/dai/nl/426286189, Nagabushan, S., Saletta, F., Heuvel, ing. J.M.W. van den (Radboud University) DAI=info:eu-repo/dai/nl/314445242, Muradjan, G., Brunner, prof. dr. H.G. (Radboud University) DAI=info:eu-repo/dai/nl/112228682, Kremer, L.C.M., Guchelaar, H.J., McCowage, G., Caron, H.N., Cleton-Jansen, A.M., Gelderblom, A.J.   +29 more
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