Results 61 to 70 of about 181,577 (204)
The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing ανβ3 integrin in chick embryo and nude mouse models. [PDF]
, 2016 Echistatin, a cyclic RGD peptide, which is an antagonist of αvβ3 integrin (disintegrin), inhibited human osteosarcoma in the chick chorioallontoic membrane (CAM) model and tumor growth and pulmonary metastases in a nude mouse orthotopic model.
Bouvet, Michael +6 more
core +4 more sources
Archives of Pathology & Laboratory Medicine, 2012 Osteosarcoma is one of the most common primary malignant bone tumors in children and adolescents. Telangiectatic osteosarcoma is an unusual variant of osteosarcoma, forming 3% to 10% of all osteosarcomas. Radiographically, these tumors appear as purely lytic destructive lesions located in the metaphyses of long bones.
Nikhil A, Sangle, Lester J, Layfield
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Extraskeletal osteosarcoma [PDF]
Cancer, 1987 A retrospective study of 88 cases of extraskeletal osteosarcoma revealed that this tumor affects adults almost exclusively, with a high incidence in patients older than 50 years, and is slightly more common in males (58%) than in female patients. The tumor occurred principally as a soft tissue mass in an extremity, with a predilection for the thighs ...
E B, Chung, F M, Enzinger
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HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma
Journal of Experimental & Clinical Cancer Research, 2018 Background Osteosarcoma is the most common primary bone tumor in children and adolescents. Unfortunately, osteosarcoma treatments often fail due to the development of chemoresistance, of which the underlying molecular mechanisms still remain unclear.
Xin Xiao +9 more
doaj +1 more source
Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines. [PDF]
, 2012 Despite significant advancements in osteosarcoma research, the overall survival of canine and human osteosarcoma patients has remained essentially static over the past 2 decades.
Chen, Xinbin +5 more
core +2 more sources
Tumor Biology, 2017 We aimed to study the anti-tumor effects of triptolide on osteosarcoma and the related molecular mechanisms. The cell viability, apoptosis portion, tumor size, tumor weight, and invasion of osteosarcoma cells were determined.
Chunming Jiang +8 more
doaj +1 more source
New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration [PDF]
, 2018 The mortality rate for malignant melanoma (MM) is very high, since it is highly invasive and resistant to chemotherapeutic treatments. The modulation of some transcription factors affects cellular processes in MM.
Antoniazzi, Franco +19 more
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Rheumatology and Therapy, 2016 Osteosarcoma (OS) is the most common primary malignancy of bone and patients with metastatic disease or recurrences continue to have very poor outcomes. Unfortunately, little prognostic improvement has been generated from the last 20 years of research and a new perspective is warranted.
Lindsey, Brock A. +2 more
openaire +2 more sources
PLoS ONE, 2014 Osteosarcoma, the most common primary bone tumor in children and young adolescents, is characterized by local invasion and distant metastasis. But the detailed mechanisms of osteosarcoma metastasis are not well known.
Yun-Shan Guo +11 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Gain-of-function of mutant p53 is associated with a high rate of lung metastasis in osteosarcoma. To investigate the mechanism of mutant p53-induced osteosarcoma metastasis, expression array analysis was performed, comparing non ...
Yanqin Zhang +15 more
doaj +1 more source