Results 61 to 70 of about 126,514 (307)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1. [PDF]

PLoS ONE, 2011
BACKGROUND: The cellular and molecular mechanisms of tumour response following chemotherapy are largely unknown. We found that low dose anti-tumour agents up-regulate early growth response 1 (EGR1) expression. EGR1 is a member of the immediate-early gene
Yukihiro Matsunoshita, Kosei Ijiri, Yasuhiro Ishidou, Satoshi Nagano, Takuya Yamamoto, Hiroko Nagao, Setsuro Komiya, Takao Setoguchi   +7 more
doaj   +1 more source

Osteosarcoma costal [PDF]

, 2011
I El Prof. Luque presenta la historia clínica, con dos ilustraciones, de un joven con un tumor localizado en la región intervértebro-escapular derecha.
Luque, Manuel José
core  

Fibroblastic growth factor receptor 1 amplification in osteosarcoma is associated with poor response to neo-adjuvant chemotherapy. [PDF]

, 2014
Osteosarcoma, the most common primary bone sarcoma, is a genetically complex disease with no widely accepted biomarker to allow stratification of patients for treatment.
M. Fernanda Amary, Behjati, S., Ye, H., Berisha, F, Strauss, S.J., Lehovsky, K., Campbell, P.J., Frezza, A.M., Presneau, Nadège, Pillay, N., Fernanda Amary, M., Bhavisha Khatri, Tarpey, P, Tarpey, P., Pillay, N, Adrienne M. Flanagan, Sam Behjati, Fernanda Amary, M, Tirabosco, R, Patrick Tarpey, Tirabosco, R., Peter J. Campbell, Roberto Tirabosco, Presneau, N, Nischalan Pillay, Khatri, B., Georgina Forbes, Frezza, AM, Flanagan, AM, Fitim Berisha, Anna M. Frezza, Campbell, PJ, Nadège Presneau, Strauss, SJ, Lehovsky, K, Khatri, B, Forbes, G., Sandra J. Strauss, Forbes, G, Behjati, S, Hongtao Ye, Berisha, F., Flanagan, A.M., Ye, H, Katie Lehovsky   +44 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

Journal of Experimental & Clinical Cancer Research, 2018
Background Osteosarcoma is the most common primary bone tumor in children and adolescents. Unfortunately, osteosarcoma treatments often fail due to the development of chemoresistance, of which the underlying molecular mechanisms still remain unclear.
Xin Xiao, Wei Wang, Yuqian Li, Di Yang, Xiaokang Li, Chao Shen, Yan Liu, Xianzhu Ke, Shuo Guo, Zheng Guo   +9 more
doaj   +1 more source

3D Printed Multifunctional PEEK Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis

, 2021
In this work, we developed the first 3D PEEK based bone scaffold with multi-functions targeting challenging bone diseases such as osteosarcoma and osteomyelitis.
Zhongyang, Lin, Meixuan, Du, Miaomiao, He, dan, Sun, Li, Zhang, Ce, zhu, Leizhen, Huang, Yubao, Li, Jingcheng, Wang, Limin, Liu, Juehan, Wang, Yueming, Song, Ganjun, Feng, Yong, Huang   +13 more
core   +1 more source