Results 11 to 20 of about 1,642,432 (258)
Characterization of the development of the mouse cochlear epithelium at the single cell level
Nature Communications, 2020 How the development of the cochlear epithelium is regulated is unclear. Here, the authors use single cell RNAseq analysis to provide insight into the transcriptional changes arising during development of the murine cochlear inner and outer hair cells.
Likhitha Kolla +13 more
doaj +1 more source
Community ecology of the ‘other’ parasitoids [PDF]
Current Opinion in Insect Science, 2016 The study of parasitoid communities is an active and dynamic field. Most studies, however, are focused primarily on parasitic wasps, despite the thousands of other insect parasitoids distributed across many lineages. Although questions in parasitoid community ecology are much the same for different groups, answers to these questions may not be due to ...
openaire +4 more sources
OncoImmunology, 2018 Intrinsic resistance to cytotoxic T-lymphocyte (CTL) killing limits responses to immune activating anti-cancer therapies. Here, we established that activation of the G2/M cell cycle checkpoint results in tumor cell cycle pause and protection from ...
Lillian Sun +9 more
doaj +1 more source
OncoImmunology, 2019 Tumor cells activate the G2/M cell cycle checkpoint in response to ionizing radiation (IR) and effector immune cell-derived granzyme B to facilitate repair and survival. Wee1 kinase inhibition reverses the ability of tumor cells to pause at G2/M.
Priya Patel +9 more
doaj +1 more source
Shedding light on optical cochlear implant progress
EMBO Molecular Medicine, 2020 Electrical cochlear implants (CI) currently lack the frequency and intensity resolution to allow detection of complex sounds in background noise. The use of microscale optoelectronics in conjunction with optogenetics provides a promising direction in CI ...
Siân R Kitcher, Catherine JC Weisz
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2023 Usher syndrome is the most common cause of deafness-blindness in the world. Usher syndrome type 1B (USH1B) is associated with mutations in MYO7A. Patients with USH1B experience deafness, blindness, and vestibular dysfunction.
Samantha C. Lau +14 more
doaj +1 more source
OncoImmunology, 2018 Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration of wild-type human TP53 cDNA in murine oral cancer ...
Ellen C. Moore +8 more
doaj +1 more source
OncoImmunology, 2018 Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB).
Megan Morisada +9 more
doaj +1 more source
eLife, 2020 Directional sensitivity of hair cells (HCs) is conferred by the aymmetric apical hair bundle, comprised of a kinocilium and stereocilia staircase. The mother centriole (MC) forms the base of the kinocilium and the stereocilia develop adjacent to it ...
Yosuke Tona, Doris K Wu
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Genetic Hearing Loss Associated With Autoinflammation
Frontiers in Neurology, 2020 Sensorineural hearing loss can result from dysfunction of the inner ear, auditory nerve, or auditory pathways in the central nervous system. Sensorineural hearing loss can be associated with age, exposure to ototoxic drugs or noise, or mutations in ...
Hiroshi Nakanishi +10 more
doaj +1 more source