Results 61 to 70 of about 25,812,695 (293)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Appel à propositions COCE 2025 (communication environnementale)

L'International Environmental Communication Association (IECA), en collaboration avec l' École des arts créatifs et des médias (CAM) de l'Université de Tasmanie , est heureuse d'annoncer que l' appel à propositions pour la 18e Conférence biennale sur la ...
COMMUNICATION, Catherine
core   +1 more source

AAV2.7m8 is a powerful viral vector for inner ear gene therapy

Nature Communications, 2019
Adeno-associated virus is used in gene therapy in mouse models of hearing loss. Here the authors compare vectors and find AAV2.7m8 can infect cells in the inner ear with high efficiency.
Kevin Isgrig, Devin S. McDougald, Jianliang Zhu, Hong Jun Wang, Jean Bennett, Wade W. Chien   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Self and other in communication and cognition : the role of auto-communication and intersubjectivity in autopoiesis of psychic systems

, 2008
By referring to Niklas Luhmann's theory of self-referential systems, Aldo Mascareño (2008, submitted for publication) gives an account of system-environment interrelatedness, explaining how social and individual constitute each other through the process ...
Märtsin, Mariann
core   +1 more source

Public information and mass media in population communication programs [PDF]

, 1977
"This project was supported by the Office of Population, U.S. Agency for International Development, AID/csd-1059."For more about the East-West Center, see http://www.eastwestcenter.org/The paper is an analysis of the public information component of ...
Glattbach, Jack, East-West Communication Institute   +1 more
core   +1 more source

Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells

eLife, 2017
The asymmetric location of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure.
Tao Jiang, Katie Kindt, Doris K Wu
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Slc26a4-insufficiency causes fluctuating hearing loss and stria vascularis dysfunction

Neurobiology of Disease, 2014
SLC26A4 mutations can cause a distinctive hearing loss phenotype with sudden drops and fluctuation in patients. Existing Slc26a4 mutant mouse lines have a profound loss of hearing and vestibular function, with severe inner ear malformations that do not ...
Taku Ito, Xiangming Li, Kiyoto Kurima, Byung Yoon Choi, Philine Wangemann, Andrew J. Griffith   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source