Results 71 to 80 of about 25,812,695 (293)

Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

Journal for ImmunoTherapy of Cancer, 2018
Background Natural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes.
Jay Friedman, Megan Morisada, Lillian Sun, Ellen C. Moore, Michelle Padget, James W. Hodge, Jeffrey Schlom, Sofia R. Gameiro, Clint T. Allen   +8 more
doaj   +1 more source

Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea

Frontiers in Molecular Neuroscience, 2020
Hearing loss is a problem that impacts a significant proportion of the adult population. Cochlear hair cell (HC) loss due to loud noise, chemotherapy and aging is the major underlying cause.
Michael Hoa, Rafal Olszewski, Xiaoyi Li, Ian Taukulis, Shoujun Gu, Alvin DeTorres, Ivan A. Lopez, Ivan A. Lopez, Fred H. Linthicum Jr., Fred H. Linthicum Jr., Akira Ishiyama, Akira Ishiyama, Daniel Martin, Robert J. Morell, Matthew W. Kelley   +14 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Cell-Specific Transcriptional Responses to Heat Shock in the Mouse Utricle Epithelium

Frontiers in Cellular Neuroscience, 2020
Sensory epithelia of the inner ear contain mechanosensory hair cells (HCs) and glia-like supporting cells (SCs), both of which are required for hearing and balance functions.
Erica Sadler, Matthew M. Ryals, Matthew M. Ryals, Lindsey A. May, Daniel Martin, Daniel Martin, Nora Welsh, Erich T. Boger, Robert J. Morell, Ronna Hertzano, Ronna Hertzano, Ronna Hertzano, Lisa L. Cunningham   +12 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

An approach to training in population communication [PDF]

, 1972
For more about the East-West Center, see http://www.eastwestcenter.org/This paper provides information on the distinctions between training and other forms of learning activities and on the role of explicit or implicit objectives in determining types of ...
Welden, Terry A., Ellingsworth, Huber Winton, Rosario, Florangel Z. (Florangel Zuleta)   +2 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Mustapha ELOUIZI (2020), Communication de crise. Crise de communication. De la pandémie à l’« infodémie »

, 2023
La crise de communication pendant la COVID-19 est le sujet principal de cet ouvrage de l’universitaire marocain Mustapha Elouizi. Après avoir discuté quelques théories de la communication, l’auteur montre principalement que l’agir communicationnel a ...
Abdelouahed Hajji, Hajji, Abdelouahed
core   +1 more source

Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers

Biology Open, 2018
The utricle of the inner ear, a vestibular sensory structure that mediates perception of linear acceleration, is comprised of two morphologically and physiologically distinct types of mechanosensory hair cells, referred to as Type Is and Type IIs.
Stephen McInturff, Joseph C. Burns, Matthew W. Kelley   +2 more
doaj   +1 more source