In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Quality assessment reporting checklists for microsimulation models: A scoping review protocol. [PDF]
de Oliveira C.
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Correction: PAHG: the database of human multi-gene families. [PDF]
Azhar R +8 more
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Television and computer use and dementia risk in older adults with limited leisure or social activities: A prospective cohort study. [PDF]
Li J +7 more
europepmc +1 more source
Revisiting co-expression-based automated function prediction in yeast with neural networks and updated Gene Ontology annotations. [PDF]
McGuire CE, Hibbs MA.
europepmc +1 more source
A cross-dataset harmonized intrusion detection framework with statistically validated multi-model learning. [PDF]
Mishra S +3 more
europepmc +1 more source
Gaming disorder: Prevalence and association with psychosocial outcomes in the German general adult population. [PDF]
Hajek A +4 more
europepmc +1 more source

