Results 111 to 120 of about 1,856,164 (287)

Langley Research Center Standard for the Evaluation of Socket Welds [PDF]

, 1985
A specification utilized for the nondestructive evaluation of socket type pipe joints at Langley Research Center (LaRC) is discussed. The scope of hardware shall include, but is not limited to, all common pipe fittings: tees, elbows, couplings, caps, and
Berry, R. F., Jr.
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Magnetic Substrates for Tissue Engineering—A Review

Magnetochemistry
Tissue engineering is based on combining cells with suitable scaffolds and growth factors. Recently, bone tissue engineering has been especially investigated deeply due to a large number of bone-related diseases.
Tomasz Blachowicz, Andrea Ehrmann
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Charles Marcellis and Arthur Vierendeel: a century of Belgian bridge building (1835-1940) [PDF]

, 2012
The Belgian bridge builders Charles Marcellis (1798-1864) and Arthur Vierendeel (1852-1940) were jack-of-all-trades in the 19th century, but both were mostly known as bridge designers, trying to have a grip on new structural possibilities.
Bertels, Inge, Collette, Quentin, De Meyer, Ronald, Verswijver, Koen, Wouters, Ine   +4 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Atomically sharp non-classical ripples in graphene

, 2020
A fundamental property of a material is the measure of its deformation under applied stress. After studying the mechanical properties of bulk materials for the past several centuries, with the discovery of graphene and other two-dimensional materials, we
Banerjee, Riju, Granzier-Nakajima, Tomotaroh, Hudson, Eric William, Pabbi, Lavish, Terrones, Mauricio   +4 more
core  

New trends in Reverse-Engineering: Augmented-Semantic models for redesign of existing objects [PDF]

, 2010
sous la coordination de Paolo BartoloInternational audienceReverse engineering is an approach that is used in many domains like electrical engineering, computer sciences and many others.
Bernard, Alain, Durupt, Alexandre,, Laroche, Florent, Remy, Sébastien   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Detachable joints of details from the carbon fiber composite [PDF]

, 2016
Nowadays the constructions from metals, plastic and filled plastics that contain detachable joints of details are widely applied in various constructions, machine components, building, mechanical engineering and other branches.
Dovgopolov, A.
core