Results 71 to 80 of about 6,287,948 (363)

Modelling Stabilometric Time Series [PDF]

open access: yes, 2010
Stabilometry is a branch of medicine that studies balance-related human functions. Stabilometric systems generate time series. The analysis of these time series using data mining techniques can be very useful for domain experts.
Caraça-Valente Hernández, Juan Pedro   +3 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

When complexity science meets implementation science: a theoretical and empirical analysis of systems change

open access: yesBMC Medicine, 2018
BackgroundImplementation science has a core aim – to get evidence into practice. Early in the evidence-based medicine movement, this task was construed in linear terms, wherein the knowledge pipeline moved from evidence created in the laboratory through ...
J. Braithwaite   +4 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

Capturing Scientific Knowledge on Medical Risk Factors [PDF]

open access: yes, 2015
In this paper, we describe a model for representing scientific knowledge of risk factors in medicine in an explicit format which enables its use for automated reasoning. The resulting model supports linking the conclusions of up-to-date clinical research
Domingue, John   +5 more
core  

Aided diagnosis of structural pathologies with an expert system [PDF]

open access: yes, 2013
Sustainability and safety are social demands for long-life buildings. Suitable inspection and maintenance tasks on structural elements are needed for keeping buildings safely in service.
Bernat Masó, Ernest, Gil Espert, Lluís
core   +2 more sources

The potential for new donkey farming systems to supply the growing demand for hides [PDF]

open access: yes, 2020
The demand for donkey hides for ejiao, a Traditional Chinese Medicine, has resulted in rapidly increasing prices for donkey hides and donkeys. This has put pressure on donkey populations globally and has implications for donkey welfare and the ...
Bennett, Richard, Pfuderer, Simone
core   +1 more source

The toxicity assessment of extract of Peganum harmala L. seeds in Caenorhabditis elegans

open access: yesBMC Complementary Medicine and Therapies, 2020
Background Peganum harmala L. is a medicinal herb extensively used in traditional Chinese medicine (TCM). So far, relevant reports on the toxicity of Peganum harmala L. seeds (PHS) are hardly available.
Xiangzhen Miao   +9 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

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