Results 61 to 70 of about 1,551,395 (273)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Connotations of the comedic text between the internal and external levels in the cinematic film... The Modern Times film as an example

الاكاديمي
The main function of film discourse is its ability to present ideas, connotations, and meanings and deliver them to the recipient, and because the comedy text is one of those film discourses that communicates its philosophical ideas by presenting them ...
Salah Mohammed Taha
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Ownership and Property in Communist Civil Codes of Czechoslovakia

Acta Iuris Stetinensis, 2019
The distribution of property in society is a fundament of communist ideology, which in Czechoslovakia was regulated by two Civil Codes. In the process of reforming the entire legal system, the purpose of both codes was, besides property regulation, also ...
Petr Bělovský
doaj   +3 more sources

Scientometric dimensions of technical reports from Bhabha Atomic Research Centre [PDF]

, 2002
Technical report is one of the media to record the scientific information generated by scientists and engineers, Bhabha Atomic Research Centre (BARC) published 554 technical reports during 1990-99 under the categories: External (373) and Internal (181 ...
Kalyane, V. L., Swarna, T., Vijai Kumar, *   +2 more
core  

Network codes with deadlines [PDF]

, 2008
We investigate the effect of decoding deadlines on network coding capacity, specifically, the capacity curve of a network as a function of the allowed delay from the time a set of bits is transmitted by the source to the time it is fully decoded by the ...
Effros, Michelle, Erez, Elona, Ho, Tracey   +2 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Assessment of cancer risk associated with 7‐nitroso‐3‐(trifluoromethyl)‐5,6,7,8‐tetrahydro[1,2,4] triazolo‐[4,3‐a]pyrazine‐contaminated sitagliptin use: A retrospective cohort study

Journal of Diabetes Investigation
Aims/Introduction A recent US Food and Drug Administration report highlighted concerns over nitrosamine (7‐nitroso‐3‐(trifluoromethyl)‐5,6,7,8‐tetrahydro[1,2,4] triazolo‐[4,3‐a]pyrazine [NTTP]) impurities in sitagliptin, prompting investigations into its
Takehiro Sugiyama, Takashi Furuno, Yuichi Ichinose, Masao Iwagami, Noriko Ihana‐Sugiyama, Kenjiro Imai, Tamaki Kakuwa, Ryoko Rikitake, Mitsuru Ohsugi, Takahiro Higashi, Hiroyasu Iso, Kohjiro Ueki   +11 more
doaj   +1 more source

Positive predictive value of ICD-10 codes for acute myocardial infarction in Japan: a validation study at a single center

BMC Health Services Research, 2018
Background In Japan, several large healthcare databases have become available for research since the early 2000’s. However, validation studies to examine the accuracy of these databases remain scarce.
Takashi Ando, Nobuhiro Ooba, Mayumi Mochizuki, Daisuke Koide, Koichi Kimura, Seitetz L. Lee, Soko Setoguchi, Kiyoshi Kubota   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source