Results 71 to 80 of about 898 (202)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Mixed-Methods Evaluation of Massachusetts’ Neonatal Abstinence Syndrome Surveillance System, 2020–2022

AJPM Focus
Introduction: The Massachusetts Department of Public Health established neonatal abstinence syndrome surveillance as an active, state-wide, population-based system using the Council of State and Territorial Epidemiologists (Tier 1) neonatal abstinence ...
Alyssa M. Pochkar, MPH, Hanna M. Shephard, MPH, Mahsa M. Yazdy, PhD, Eirini Nestoridi, MD   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Ends and Ways: The Algorithmic Politics of Network Neutrality [PDF]

Global Media Journal: Canadian Edition, 2010
The Internet in Canada is an assemblage of private and public networks. A variety of institutions and networking codes manage these networks. Conflicts exist between these parties despite their interconnection.
Fenwick McKelvey
doaj  

The 3A non-structural-protein coding region of the southern African SAT type isolates differs from that of other foot-and-mouth disease viruses.

The Onderstepoort journal of veterinary research, 2002
The 3A non-structural protein of foot-and-mouth disease viruses is a relatively conserved protein comprising 153 amino acids. Recent studies have demonstrated correlation between mutations in the 3A non-structural-protein-coding region, including a 10-amino acid deletion, and attenuation of the viruses in cattle.
L E, Heat, H G, Van Rensburg, W, Vosloo, L H, Nel   +3 more
openaire   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Developing and testing a framework for coding general practitioners’ free-text diagnoses in electronic medical records - a reliability study for generating training data in natural language processing

BMC Primary Care
Background Diagnoses entered by general practitioners into electronic medical records have great potential for research and practice, but unfortunately, diagnoses are often in uncoded format, making them of little use.
Audrey Wallnöfer, Jakob M. Burgstaller, Katja Weiss, Thomas Rosemann, Oliver Senn, Stefan Markun   +5 more
doaj   +1 more source

Interaction of Industry Development with its Encoding in Rceat: Experience of Veterinary Medication Production

Вестник Российского экономического университета имени Г. В. Плеханова
In public space prospects of development of industries in Russian economy that put out new goods and services are often connected with giving these industries relative codes in the Russian Classifier of Economic Activity Types (RCEAT).
G. M. Samoilov
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source