Results 161 to 170 of about 24,961 (203)
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Otolaryngologic Clinics of North America, 1993
The aminoglycoside antibiotics are active bactericidal agents used for the treatment of tuberculosis and gram-negative bacterial infections. Well over 2 million patients per year receive aminoglycosides; however, a major limitation to their use is ototoxicity (cochleotoxicity and vestibulotoxicity), nephrotoxicity, and neuromuscular blockade ...
C M, Henley, L P, Rybak
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The aminoglycoside antibiotics are active bactericidal agents used for the treatment of tuberculosis and gram-negative bacterial infections. Well over 2 million patients per year receive aminoglycosides; however, a major limitation to their use is ototoxicity (cochleotoxicity and vestibulotoxicity), nephrotoxicity, and neuromuscular blockade ...
C M, Henley, L P, Rybak
openaire +2 more sources
Cisplatin-Induced Ototoxicity: Updates on Molecular Targets.
Trends in Molecular Medicine, 2019Cis-diamminedichloridoplatinum (II) (cisplatin) is a chemotherapeutic drug currently prescribed for the treatment of many types of human cancer, but its use is associated with numerous adverse effects, one of which is ototoxicity.
E. Gentilin +4 more
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Drug‐Induced Ototoxicity: A Comprehensive Review and Reference Guide
Pharmacotherapy, 2020In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications ...
H. Rizk +5 more
semanticscholar +1 more source
American Journal of Otolaryngology, 1986
The author participated in two prospective studies of patients receiving aminoglycoside antibiotics. In the first study, 54 patients received amikacin, and 54 received gentamicin. In the second study, 61 patients received gentamicin, 50 received netilmicin, and 52 received tobramycin.
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The author participated in two prospective studies of patients receiving aminoglycoside antibiotics. In the first study, 54 patients received amikacin, and 54 received gentamicin. In the second study, 61 patients received gentamicin, 50 received netilmicin, and 52 received tobramycin.
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Drugs of Today, 2003
Over the last 10 years new information has been published providing a better understanding of the risk factors, mechanism and prevention of aminoglycoside ototoxicity. The use of a higher dose and once-daily intravenous administration of aminoglycosides has shown clinical effectiveness with no increase in ototoxicity when compared to traditional ...
openaire +2 more sources
Over the last 10 years new information has been published providing a better understanding of the risk factors, mechanism and prevention of aminoglycoside ototoxicity. The use of a higher dose and once-daily intravenous administration of aminoglycosides has shown clinical effectiveness with no increase in ototoxicity when compared to traditional ...
openaire +2 more sources
Ferrostatin-1 protects auditory hair cells from cisplatin-induced ototoxicity in vitro and in vivo.
Biochemical and Biophysical Research Communications - BBRC, 2020Cisplatin is used in a wide variety of malignancies, but cisplatin-induced ototoxicity remains a major issue in clinical practice. Experimental evidence indicates that ferroptosis plays a key role in mediating the unwanted cytotoxicity effect caused by ...
Bing Hu +7 more
semanticscholar +1 more source
Toxicology Letters, 2020
Cisplatin is a well-known and commonly used chemotherapeutic agent. However, cisplatin-induced ototoxicity limits its clinical use. Previous studies have shown an important role of reactive oxygen species (ROS) accumulation in the pathogenesis of ...
Weijian Zhang +9 more
semanticscholar +1 more source
Cisplatin is a well-known and commonly used chemotherapeutic agent. However, cisplatin-induced ototoxicity limits its clinical use. Previous studies have shown an important role of reactive oxygen species (ROS) accumulation in the pathogenesis of ...
Weijian Zhang +9 more
semanticscholar +1 more source
Toxicology in Vitro, 2020
Some drugs have the potential to cause cellular degeneration of cochlear and/or vestibular system, leading to temporary or permanent hearing loss, innitus, ataxia, dizziness, ear infections, hyperacusis, vertigo, nystagmus and other ear problems.
Hui Zhang +5 more
semanticscholar +1 more source
Some drugs have the potential to cause cellular degeneration of cochlear and/or vestibular system, leading to temporary or permanent hearing loss, innitus, ataxia, dizziness, ear infections, hyperacusis, vertigo, nystagmus and other ear problems.
Hui Zhang +5 more
semanticscholar +1 more source
Cyclodextrin polymer improves atherosclerosis therapy and reduces ototoxicity.
Journal of Controlled Release, 2019Recently, cyclodextrin (CD) has shown the potential for effective treatment of atherosclerotic plaques in mice by solubilizing plaque cholesterol. While promising as a new therapy for atherosclerosis, poor pharmacokinetics and ototoxicity of CD pose a ...
Heegon Kim, Junhee Han, Ji-Ho Park
semanticscholar +1 more source