Results 151 to 160 of about 4,708 (180)

Ototoxicity: mechanisms, protective agents, and monitoring

Current Opinion in Otolaryngology & Head and Neck Surgery, 2000
In the past year, progress has been made not only in elucidating the mechanisms of ototoxicity but also in finding otoprotective agents. For aminoglycosides, new dosing protocols and protective agents, including growth factors and salicylates, show promise for eventually reducing ototoxicity ...
Kathleen C.M. Campbell, James Kalkanis, F. Robert Glatz   +2 more
openaire   +1 more source

TEOAE monitoring of Cisplatin induced ototoxicity in guinea pigs: the protective effect of vitamin B treatment

Auris Nasus Larynx, 2001
Objective: To evaluate Cisplatin (CP) induced ototoxicity and the effects of vitamin B treatment on ototoxicity in guinea pigs by using the Transient Evoked Otoacoustic Emission (TEOAE) technique.
Enis Alpin Güneri, Bulent Şerbetçioğlu, Ahmet Ömer Ikiz   +2 more
exaly   +2 more sources

Fixed-Level Frequency Threshold Testing for Ototoxicity Monitoring

Ear & Hearing, 2017
Objectives: Hearing loss from ototoxicity is often most pronounced at high frequencies. To improve patient monitoring and compliance, high-frequency testing methods should be short and easy to administer. We evaluated the repeatability and accuracy of a Békésy-like, fixed-level frequency threshold (FLFT) technique.
Catherine C, Rieke, Odile H, Clavier, Lindsay V, Allen, Allison P, Anderson, Chris A, Brooks, Abigail M, Fellows, Douglas S, Brungart, Jay C, Buckey   +7 more
openaire   +2 more sources

High-Frequency Monitoring for Early Detection of Cisplatin Ototoxicity

Archives of Otolaryngology - Head and Neck Surgery, 1993
Cisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy to detect cisplatin-induced ototoxicity is needed ...
S A, Fausti, J A, Henry, H I, Schaffer, D J, Olson, R H, Frey, G C, Bagby   +5 more
openaire   +2 more sources

Monitoring of Cisplatin Ototoxicity by Distortion-Product Otoacoustic Emissions

Auris Nasus Larynx, 1996
Cisplatin is one of the most commonly used chemotherapeutic agents. However, ototoxicity, in particular, damage to the outer hair cells of the cochlea, is one of its major side effects. Otoacoustic emissions are acoustical signals that originate from the contractile activity of the outer hair cells. They are transmitted from the cochlea to the external
O, Ozturan, J, Jerger, H, Lew, G R, Lynch   +3 more
openaire   +2 more sources

A study of ototoxicity in adolescents and adults: Ototoxicity incidence, audiological monitoring, risk profiles and blood biomarkers

, 2023
Introduction: Nearly half of the patients who underwent chemotherapy received cisplatin as part of their regimen. Cisplatin-induced hearing loss generally starts at high frequencies first and can affect the speech frequency range after prolonged use ...
Awad, Asma Rafa. A.
openaire   +2 more sources

Audiological Monitoring for Ototoxicity in Medically Fragile Children

Seminars in Hearing, 2011
Risk for hearing loss due to medical interventions has audiological as well as medicolegal implications. In children with life-threatening conditions, medical interventions may require great risk of morbidity to reduce mortality. Although audiologists are typically not in the position of intervening to rescue hearing, they do provide necessary and ...
Brian Fligor, Charlotte Mullen
openaire   +1 more source

High-Frequency Audiometric Monitoring for Early Detection of Aminoglycoside Ototoxicity

The Journal of Infectious Diseases, 1992
Treatment with aminoglycosides is known to cause irreversible hearing loss, typically affecting higher-frequency hearing first and progressing to lower frequencies. Standardized methodology has not been developed for early detection of ototoxicity. Serial conventional (0.25-8 kHz) and high-frequency (9-20 kHz) hearing threshold monitoring was done ...
S A, Fausti, J A, Henry, H I, Schaffer, D J, Olson, R H, Frey, W J, McDonald   +5 more
openaire   +2 more sources

Audiologic Monitoring of Ototoxicity

2014
Ototoxicity can be defined as the capacity of a drug or chemical to cause damage to the inner ear structure and\or function. This phenomenon may involve the cochlea, vestibule or both. The symptoms of ototoxicity include hearing loss, tinnitus, and vertigo. Today, the number of audiologic tests for monitoring ototoxicity has increased.
TAŞ, Abdullah, YAĞIZ, Recep
openaire   +1 more source

Otoacoustic emissions — an approach for monitoring aminoglycoside induced ototoxicity in children

International Journal of Pediatric Otorhinolaryngology, 1999
The early detection of hearing impairment caused by ototoxic drugs, such as aminoglycosides, has been the aim of research world-wide. Histopathological studies have shown that the outer hair cells are the most susceptible cochlear components to injury from ototoxic drugs like aminoglycosides.
P, Stavroulaki, N, Apostolopoulos, D, Dinopoulou, I, Vossinakis, M, Tsakanikos, D, Douniadakis   +5 more
openaire   +2 more sources