Results 171 to 180 of about 8,213 (210)

Ototoxicity: mechanisms, protective agents, and monitoring

Current Opinion in Otolaryngology & Head and Neck Surgery, 2000
In the past year, progress has been made not only in elucidating the mechanisms of ototoxicity but also in finding otoprotective agents. For aminoglycosides, new dosing protocols and protective agents, including growth factors and salicylates, show promise for eventually reducing ototoxicity ...
Kathleen C.M. Campbell, James Kalkanis, F. Robert Glatz   +2 more
openaire   +1 more source

Fixed-Level Frequency Threshold Testing for Ototoxicity Monitoring

Ear & Hearing, 2017
Objectives: Hearing loss from ototoxicity is often most pronounced at high frequencies. To improve patient monitoring and compliance, high-frequency testing methods should be short and easy to administer. We evaluated the repeatability and accuracy of a Békésy-like, fixed-level frequency threshold (FLFT) technique.
Catherine C, Rieke, Odile H, Clavier, Lindsay V, Allen, Allison P, Anderson, Chris A, Brooks, Abigail M, Fellows, Douglas S, Brungart, Jay C, Buckey   +7 more
openaire   +2 more sources

Challenges in Ototoxicity Monitoring in the Pediatric Oncology Population

Journal of the American Academy of Audiology, 2014
Background:Platinum-based chemotherapy and cranial radiation are effective treatment options commonly prescribed for a variety of childhood cancers. These therapies can, and often do, result in early- and late-onset adverse health effects such as hearing loss.
Johnnie K, Bass, Shaum P, Bhagat
openaire   +2 more sources

High-Frequency Monitoring for Early Detection of Cisplatin Ototoxicity

Archives of Otolaryngology - Head and Neck Surgery, 1993
Cisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy to detect cisplatin-induced ototoxicity is needed ...
S A, Fausti, J A, Henry, H I, Schaffer, D J, Olson, R H, Frey, G C, Bagby   +5 more
openaire   +2 more sources

Audiologic Threshold Monitoring of Patients Receiving Ototoxic Drugs

Annals of Otology, Rhinology & Laryngology, 1989
An effort was made to determine the efficacy of auditory threshold monitoring of patients receiving ototoxic drugs. Forty-four patients treated with either tobramycin or vancomycin for osteomyelitis were tested at the beginning of treatment, following treatment, and twice weekly during treatment when possible. All patients had renal function carefully
W L, Meyerhoff, G E, Maale, W, Yellin, P S, Roland   +3 more
openaire   +2 more sources

Monitoring of Cisplatin Ototoxicity by Distortion-Product Otoacoustic Emissions

Auris Nasus Larynx, 1996
Cisplatin is one of the most commonly used chemotherapeutic agents. However, ototoxicity, in particular, damage to the outer hair cells of the cochlea, is one of its major side effects. Otoacoustic emissions are acoustical signals that originate from the contractile activity of the outer hair cells. They are transmitted from the cochlea to the external
O, Ozturan, J, Jerger, H, Lew, G R, Lynch   +3 more
openaire   +2 more sources

The use of tele-audiology in ototoxicity monitoring: A scoping review

Journal of Telemedicine and Telecare, 2022
Introduction Due to the growing burden of disease in South Africa, encompassing conditions such as tuberculosis, human immunodeficiency virus, and cancer, the holistic management of affected patients incorporating ototoxicity monitoring is a necessity. However, ototoxicity monitoring in developing countries may be limited due to a lack of resources and
Nazeera Peerbhay, Danielle R Munsamy, Hombisa P Dlamini, Fisokuhle Langa, Jessica Paken   +4 more
openaire   +2 more sources

Audiological Monitoring for Ototoxicity in Medically Fragile Children

Seminars in Hearing, 2011
Risk for hearing loss due to medical interventions has audiological as well as medicolegal implications. In children with life-threatening conditions, medical interventions may require great risk of morbidity to reduce mortality. Although audiologists are typically not in the position of intervening to rescue hearing, they do provide necessary and ...
Brian Fligor, Charlotte Mullen
openaire   +1 more source

Progressive ototoxicity of neomycin monitored using derived brainstem response audiometry

Hearing Research, 1985
Progressive hearing loss following the systemic administration of neomycin was investigated using derived brainstem response audiometry. Cats were given three to five times the maximum recommended clinical dose of neomycin over a period of 10 days.
Shepherd, R. K., Clark, Graeme M.
openaire   +2 more sources

High-Frequency Audiometric Monitoring for Early Detection of Aminoglycoside Ototoxicity

The Journal of Infectious Diseases, 1992
Treatment with aminoglycosides is known to cause irreversible hearing loss, typically affecting higher-frequency hearing first and progressing to lower frequencies. Standardized methodology has not been developed for early detection of ototoxicity. Serial conventional (0.25-8 kHz) and high-frequency (9-20 kHz) hearing threshold monitoring was done ...
S A, Fausti, J A, Henry, H I, Schaffer, D J, Olson, R H, Frey, W J, McDonald   +5 more
openaire   +2 more sources