Results 81 to 90 of about 506,839 (244)
Dosimetric evaluation in breast tumours: comparison of three techniques
Saúde & Tecnologia, 2015 Purpose – To compare the conventional technique, the technique of mixed energies and the technique field-in-field with mixed energies, checking the received dose in organs at risk and target volume.
João Marques +5 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Editorial: Out-of-field second primary cancer induction: Dosimetry and modelling
Frontiers in Oncology, 2022 Beatriz Sánchez-Nieto +6 more
doaj +1 more source
Frontiers in OncologyMore and more accelerator-based boron neutron capture therapy (AB-BNCT) facilities are under the construction or commissioning stage, and the neutron beam characteristic measurements at each facility will start soon.
Zhen-Fan You +2 more
doaj +1 more source
Out-of-field doses in radiotherapy treatments of paediatric patients
, 2021 Out-of-field doses are delivery to healthy tissues, which may allow the development of second tumours. Its evaluation with MC methods is essential since these doses are inaccurate when calculated by TPSs. The use of IMRT has been discussed, especially in paediatric patients, as it leads to a "bath" of low doses to large volumes of out-of-field tissue ...
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Photon and Neutron Dose Estimation Using Monte Carlo Simulation in TrueBeam’s Room
Journal of Medical PhysicsPurpose: The distribution of neutron ambient dose equivalent within the TrueBeam 10 MV photon chamber was investigated. Materials and Methods: The research used particle and heavy ion transport code system (PHITS) code and JENDL-5.0 to simulate the ...
Soai Dang Quoc +3 more
doaj +1 more source