Results 81 to 90 of about 3,411,169 (350)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A mechanism of protein localization : the signal hypothesis and bacteria [PDF]

, 1980
We are studying the molecular mechanism of cellular protein localization. The availability of genetic techniques, such as gene fusion in Escherichia coli, has made this problem particularly amenable to study in this prokaryote.
Hall, M. N., Silhavy, T. J., Emr, S. D., T J Silhavy, S D Emr, M N Hall   +5 more
core   +1 more source

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

eLife, 2019
During apoptosis, Bcl-2 proteins such as Bax and Bak mediate the release of pro-apoptotic proteins from the mitochondria by clustering on the outer mitochondrial membrane and thereby permeabilizing it.
Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski   +6 more
doaj   +1 more source

The bacterial outer membrane is an evolving antibiotic barrier

Proceedings of the National Academy of Sciences of the United States of America, 2018
The outer membrane (OM) of the diderm “gram-negative” class of bacteria is an essential organelle and a robust permeability barrier that prevents many antibiotics from reaching their intracellular targets (1).
Kerrie L. May, Marcin Grabowicz
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Lipopolysaccharide is inserted into the outer membrane through an intramembrane hole, a lumen gate, and the lateral opening of LptD

, 2015
C.D. is a recipient of the Wellcome Trust New Investigator Award. P.J.S. is supported by BBSRC grant BB/I019855/1 and W.W. is supported by China Natural Science Foundation of Guangdong Province grant (S2013010016539).
Stansfeld, P., Dong, H., Stansfeld, Phillip J., Zeng, Y., Wang, W., Gu, Y., Dong, Changjiang, Dong, C., Gu, Yinghong, Dong, Haohao, Zeng, Yi, Wang, Wenjian   +11 more
core   +1 more source

Anti-outer Membrane Vesicle Antibodies Increase Antibiotic Sensitivity of Pan-Drug-Resistant Acinetobacter baumannii

Frontiers in Microbiology, 2019
Acinetobacter baumannii often causes serious nosocomial infections. Because of its serious drug resistance problems, complex drug resistance mechanism, and rapid adaptation to antibiotics, it often shows pan-drug resistance and high fatality rates, which
Weiwei Huang, Qishu Zhang, Weiran Li, Yongjun Chen, Congyan Shu, Qingrong Li, Jingxian Zhou, Chao Ye, Hongmei Bai, Wenjia Sun, Xu Yang, Yanbing Ma   +11 more
doaj   +1 more source

Phospholipid retention in the absence of asymmetry strengthens the outer membrane permeability barrier to last-resort antibiotics

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The outer membrane of Gram-negative bacteria prevents the entry of many antibiotics and limits treatment options for Gram-negative infections.
M. Powers, M. Trent
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Membrane proteins in the outer mebrane of plastids and mitochondria [PDF]

, 2006
Channels of the plastid and mitochondrial outer membranes facilitate the turnover of molecules and ions via these membranes. Although channels have been studied many questions pertaining to the whole diversity of plastid and mitochondrial channels in ...
Ilkavets, Iryna
core