Results 11 to 20 of about 586,788 (291)

Outer membrane proteins of pathogenic spirochetes [PDF]

FEMS Microbiology Reviews, 2004
Pathogenic spirochetes are the causative agents of several important diseases including syphilis, Lyme disease, leptospirosis, swine dysentery, periodontal disease and some forms of relapsing fever. Spirochetal bacteria possess two membranes and the proteins present in the outer membrane are at the site of interaction with host tissue and the immune ...
Paul A, Cullen, David A, Haake, Ben, Adler   +2 more
openaire   +2 more sources

Outer membrane protein design [PDF]

Current Opinion in Structural Biology, 2017
Membrane proteins are the gateway to the cell. These proteins are also a control center of the cell, as information from the outside is passed through membrane proteins as signals to the cellular machinery. The design of membrane proteins seeks to harness the power of these gateways and signal carriers.
openaire   +2 more sources

Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria [PDF]

, 1993
Nuclear-encoded proteins destined for mitochondria must cross the outer or both outer and inner membranes to reach their final sub- mitochondrial locations. While the inner membrane can translocate preproteins by itself, it is not known whether the outer
Lill, Roland, Mayer, Andreas, Neupert, Walter   +2 more
core   +2 more sources

A New Strain Collection for Improved Expression of Outer Membrane Proteins

Frontiers in Cellular and Infection Microbiology, 2017
Almost all integral membrane proteins found in the outer membranes of Gram-negative bacteria belong to the transmembrane β-barrel family. These proteins are not only important for nutrient uptake and homeostasis, but are also involved in such processes ...
Ina Meuskens, Ina Meuskens, Marcin Michalik, Nandini Chauhan, Dirk Linke, Jack C. Leo   +5 more
doaj   +1 more source

High yield production process for Shigella outer membrane particles. [PDF]

PLoS ONE, 2012
Gram-negative bacteria naturally shed particles that consist of outer membrane lipids, outer membrane proteins, and soluble periplasmic components. These particles have been proposed for use as vaccines but the yield has been problematic.
Francesco Berlanda Scorza, Anna Maria Colucci, Luana Maggiore, Silvia Sanzone, Omar Rossi, Ilaria Ferlenghi, Isabella Pesce, Mariaelena Caboni, Nathalie Norais, Vito Di Cioccio, Allan Saul, Christiane Gerke   +11 more
doaj   +1 more source

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]

, 2011
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham, Anna M. Salazar, Chen, Ciechanover, Clark, Cox, David C. Chan, de Godoy, Deng, Deshaies, Ding, Gautier, Gegg, Geisler, Greene, Griparic, Kirkpatrick, Korolchuk, Kuroda, Lee, Matsuda, Michael J. Sweredoski, Narendra, Narendra, Narendra, Narendra, Natalie J. Kolawa, Nickie C. Chan, Okatsu, Ong, Pagliarini, Palacino, Pallanck, Park, Poole, Poole, Rappsilber, Robert L.J. Graham, Shimura, Song, Sonja Hess, Sou, Tai, Tanaka, Twig, Vives-Bauza, Yang, Yao, Ziviani, Ziviani   +49 more
core   +3 more sources

Insights into outer membrane protein crystallization [PDF]

Molecular Membrane Biology, 2008
Outer membrane proteins are structurally distinct from those that reside in the inner membrane and play important roles in bacterial pathogenicity and human metabolism. X-ray crystallography studies on >40 different outer membrane proteins have revealed that the transmembrane portion of these proteins can be constructed from either beta-sheets or less ...
Newstead, S, Hobbs, J, Jordan, D, Carpenter, E, Iwata, S   +4 more
openaire   +3 more sources

A Hidden Markov Model method, capable of predicting and discriminating β-barrel outer membrane proteins

BMC Bioinformatics, 2004
Background Integral membrane proteins constitute about 20–30% of all proteins in the fully sequenced genomes. They come in two structural classes, the α-helical and the β-barrel membrane proteins, demonstrating different physicochemical characteristics ...
Hamodrakas Stavros J, Spyropoulos Ioannis C, Liakopoulos Theodore D, Bagos Pantelis G   +3 more
doaj   +1 more source

Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria. [PDF]

, 2017
SCL25A46 is a mitochondrial carrier protein that surprisingly localizes to the outer membrane and is distantly related to Ugo1. Here we show that a subset of SLC25A46 interacts with mitochondrial dynamics components and the MICOS complex.
Claypool, Steven M, Jen, Joanna C, Koehler, Carla M, Steffen, Janos, Vashisht, Ajay A, Wan, Jijun, Wohlschlegel, James A   +6 more
core   +1 more source

Evolutionary pathways of repeat protein topology in bacterial outer membrane proteins

eLife, 2018
Outer membrane proteins (OMPs) are the proteins in the surface of Gram-negative bacteria. These proteins have diverse functions but a single topology: the β-barrel.
Meghan Whitney Franklin, Sergey Nepomnyachyi, Ryan Feehan, Nir Ben-Tal, Rachel Kolodny, Joanna SG Slusky   +5 more
doaj   +1 more source