Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of <i>Treponema pallidum</i> outer membrane proteins. [PDF]
Bettin EB +27 more
europepmc +1 more source
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source
Immunochemical characterization of variable epitopes of outer membrane protein P2 of nontypeable Haemophilus influenzae [PDF]
L van Alphen +3 more
openalex +1 more source
Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang +12 more
wiley +1 more source
Electrophysiological Insights into Antibiotic Translocation and Resistance: The Impact of Outer Membrane Proteins. [PDF]
Ghai I.
europepmc +1 more source
De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li +23 more
wiley +1 more source
Immunoinformatics design of a multi-epitope vaccine for Chlamydia trachomatis major outer membrane proteins. [PDF]
Shetty S +5 more
europepmc +1 more source
Analysis of proteins inChlamydia trachomatisL2 outer membrane complex, COMC [PDF]
Svend Birkelund +5 more
openalex +1 more source
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min +6 more
wiley +1 more source

