Results 311 to 320 of about 590,456 (352)

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Simulations of bacterial outer membrane proteins: Towards an e-outer membrane

, 2016
Baaden, M, Sansom, M, Bond, P, Cox, K, Deol, S, Faraldo-Gomez, J, Meier, C   +6 more
openaire   +1 more source

Engineering of outer membrane proteins to increase E. coli outer membrane permeability

openaire   +2 more sources

Biogenesis of mitochondrial outer membrane proteins

Biochimica Et Biophysica Acta - Molecular Cell Research, 2009
Mitochondria are surrounded by two distinct membranes: the outer and the inner membrane. The mitochondrial outer membrane mediates numerous interactions between the mitochondrial metabolic and genetic systems and the rest of the eukaryotic cell. Proteins of this membrane are nuclear-encoded and synthesized as precursor proteins in the cytosol. They are
Doron Rapaport
exaly   +3 more sources

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Outer membrane protein evolution

Current Opinion in Structural Biology, 2021
Outer membrane proteins have remarkably homogeneous structure. They are all up down β-barrels. Up down barrels themselves are composed of repeated sets of β-hairpins. The consistency of the usage of the β-hairpin throughout the outer membrane milieu allows for interrogation of the evolution of these repetitive structures.
Rik, Dhar, Joanna Sg, Slusky
openaire   +2 more sources

Comparison of Chlamydia outer membrane complex to recombinant outer membrane proteins as vaccine

Vaccine, 2020
The Chlamydial outer membrane complex (COMC) from the elementary body (EB) is a protein rich insoluble outer membrane shell from which cytosolic proteins have been extracted with detergent. In this study we conducted mass spectrometry experiments to detect proteins in the COMC prepared from C. muridarum EB.
Leonard J Foster
exaly   +3 more sources

Folding of outer membrane proteins

Archives of Biochemistry and Biophysics, 2013
Outer membrane proteins (OMPs) represent a large group of β-barrel proteins found both in the membranes of both bacteria and eukaryotes. Their general ease of expression and refolding and straightforward methods to monitor their degree of folding conspire to make OMPs excellent model systems to investigate how the membrane environment and other ...
Daniel E Otzen
exaly   +4 more sources

Outer membrane proteins of pathogenic spirochetes [PDF]

FEMS Microbiology Reviews, 2004
Pathogenic spirochetes are the causative agents of several important diseases including syphilis, Lyme disease, leptospirosis, swine dysentery, periodontal disease and some forms of relapsing fever. Spirochetal bacteria possess two membranes and the proteins present in the outer membrane are at the site of interaction with host tissue and the immune ...
Ben Adler
exaly   +3 more sources

Import and Insertion of Proteins into the Mitochondrial Outer Membrane [PDF]

FEBS Journal, 1995
Nuclear‐encoded proteins destined for insertion into the mitochondrial outer membrane, follow the same general pathway for import as proteins that are translocated to interior compartments within the organelle. This observation is true both for β‐barrel‐type proteins and for proteins that contain hydrophobic α‐helical transmembrane segments.
Heidi May McBride, Douglas G Millar
exaly   +3 more sources