Results 91 to 100 of about 1,644,691 (285)

Delivery of Periodontopathogenic Extracellular Vesicles to Brain Monocytes and Microglial IL-6 Promotion by RNA Cargo

Frontiers in Molecular Biosciences, 2020
Gram-negative bacterial extracellular vesicles (EVs), also known as outer membrane vesicles (OMVs), are secreted from bacterial cells and have attracted research attention due to their role in cell-to-cell communication.
Jae Yeong Ha, Song-Yi Choi, Ji Hye Lee, Su-Hyung Hong, Heon-Jin Lee, Heon-Jin Lee   +5 more
doaj   +1 more source

The Borrelia afzelii outer membrane protein BAPKO_0422 binds human Factor-H and is predicted to form a membrane-spanning beta-barrel [PDF]

, 2015
The deep evolutionary history of the Spirochetes places their branch point early in the evolution of the diderms, before the divergence of the present day Proteobacteria.
Brown, G., Bingham, Richard, Bingham, R.J., Stejskal, Lenka, Laity, Peter R., Dyer, A., Laity, P.R., Stejskal, L., Dyer, Adam, Brown, Gemma   +9 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Secretory vesicles are preferentially targeted to areas of low molecular SNARE density [PDF]

, 2012
Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide sensitive factor attachment protein receptor) proteins are the catalytic core of the secretory ...
Weiping Lu (120665), Dun, Alison R., Lu, Weiping, Rory R. Duncan (120667), Weiping Lu, Gabriel J. Lord (120664), Colin Rickman (120669), Andrew Dunn, Gabriel J Lord, Martin, Kirsty J, Lei Yang (102719), Qiu, Zhen, Rickman, Colin; id_orcid, Kirsty J Martin, Lei Yang, Duncan, Rory R, Duncan, Rory R., Alison R. Dun (120660), Zhen Qiu (120662), Rickman, Colin, Dun, Alison, Qiu, Zhen; id_orcid, Colin Rickman, Rory R Duncan, Lord, Gabriel J, Kirsty J. Martin (120661), Alison R Dun, Lord, Gabriel J., Yang, Lei, Martin, Kirsty J., Andrew Dunn (120663), Dunn, Andrew, Zhen Qiu, Martin Kirsty J., Yang Lei, Duncan Rory R., Dun Alison R., Dunn Andrew, Rickman Colin, Qiu Zhen, Lu Weiping, Lord Gabriel J.   +41 more
core   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Development of an aptasensor for the detection of outer membrane vesicles derived from Escherichia coli

Nano Express
Rapid and reliable detection of bacterial pathogens is essential for clinical diagnostics and food safety monitoring. This study explores bacterial outer membrane vesicles (OMVs), nanoscale particles naturally released by Gram-negative bacteria such as ...
Shiana Malhotra, Renee V Goreham
doaj   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis [PDF]

, 2009
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial
Kepp, Oliver, Meinecke, M., Harsman, Anke, Meinecke, Michael, Joachim Rassow, Hauf, Eva, Kepp, O., Günther, Dirk, Oliver Kepp, Richard Wagner, Dirk Günther, Thomas Rudel, Hauf, E., Wagner, R., Katharina Ross, Rassow, Joachim, Volker Brinkmann, Brinkmann, Volker, Rajalingam, Krishnaraj, Ines Herrmann, Elke A. Dian-Lothrop, Brinkmann, V., Kozjak-Pavlovic, V., Günther, D., Kozjak-Pavlovic, Vera, Ross, Katharina, Eva Hauf, Vera Kozjak-Pavlovic, Michael Meinecke, Robert Hurwitz, Dian-Lothrop, E., Wagner, Richard, Ross, K., Rajalingam, K., Rudel, T., Dian-Lothrop, Elke A., Rudel, Thomas, Hurwitz, Robert, Krishnaraj Rajalingam, Harsman, A., Elke A Dian-Lothrop, Herrmann, I., Hurwitz, R., Herrmann, Ines, Rassow, J., Anke Harsman, Meinecke Michael, Wagner Richard, Hauf Eva, Ross Katharina, Dian-Lothrop Elke A., Harsman Anke, Brinkmann Volker, Günther Dirk, Kepp Oliver, Rudel Thomas, Rassow Joachim, Kozjak-Pavlovic Vera, Rajalingam Krishnaraj, Hurwitz Robert, Herrmann Ines   +60 more
core   +2 more sources

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source