Results 71 to 80 of about 84,904 (290)

Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitise Bacteria to Antibiotic Treatment [PDF]

, 2019
Outer membrane and membrane vesicles (OMV/MV) are released from bacteria and participate in cell communication, biofilm formation and host-pathogen interactions. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that catalyse post-
Brotherton, Dominik, Matewele, Paul, Mastroianni, Giulia, Kosgodage, U., Awamaria, Brigitte, Inal, Jameel M., Mastroianni, G., Inal, J.M., Lange, S., Inal, Jameel, Matewele, P., Kraev, Igor, Kosgodage, Uchini S, Nicholas, A.P., Nicholas, Anthony P., Brotherton, D., Lange, Sigrun, Awamaria, B., Kraev, I., Kosgodage, Uchini S.   +19 more
core   +1 more source

Incorporation of Heterologous Outer Membrane and Periplasmic Proteins into Escherichia coli Outer Membrane Vesicles [PDF]

Journal of Biological Chemistry, 2004
Gram-negative bacteria shed outer membrane vesicles composed of outer membrane and periplasmic components. Since vesicles from pathogenic bacteria contain virulence factors and have been shown to interact with eukaryotic cells, it has been proposed that vesicles behave as delivery vehicles.
Nicole C, Kesty, Meta J, Kuehn
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Protein-enriched outer membrane vesicles as a native platform for outer membrane protein studies [PDF]

Communications Biology, 2018
AbstractMost studies characterizing the folding, structure, and function of membrane proteins rely on solubilized or reconstituted samples. Whereas solubilized membrane proteins lack the functionally important lipid membrane, reconstitution embeds them into artificial lipid bilayers, which lack characteristic features of cellular membranes including ...
Johannes Thoma, Selen Manioglu, David Kalbermatter, Patrick D. Bosshart, Dimitrios Fotiadis, Daniel J. Müller   +5 more
openaire   +4 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Outer Membrane Vesicles as Mediators of Plant–Bacterial Interactions

Frontiers in Microbiology, 2022
Plants have co-evolved with diverse microorganisms that have developed different mechanisms of direct and indirect interactions with their host. Recently, greater attention has been paid to a direct “message” delivery pathway from bacteria to plants, mediated by the outer membrane vesicles (OMVs).
Rudnicka, Małgorzata, Noszczyńska, Magdalena, Malicka, Monika, Kasperkiewicz, Katarzyna, Pawlik, Malgorzata, Piotrowska-Sege, Zofia   +5 more
openaire   +5 more sources

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

FM1-43 reveals membrane recycling in adult inner hair cells of the mammalian cochlea [PDF]

, 2002
Neural transmission of complex sounds demands fast and sustained rates of synaptic release from the primary cochlear receptors, the inner hair cells (IHCs). The cells therefore require efficient membrane recycling.
Ashmore, JF, Griesinger, CB, Richards, CD   +2 more
core  

Coreceptor and Cytokine Concentrations May Not Explain Differences in Disease Progression Observed in HIV-1 Clade A and D Infected Ugandans [PDF]

, 2011
Background: The use of cellular coreceptors and modulation of cytokine concentrations by HIV to establish a productive infection is well documented. However, it is unknown whether the expression of these proteins affects the course of HIV clade A and D ...
Zampighi Lorenzo M., Schietroma, Cataldo, Wright Edward, Ernest M. Wright, Parkes-Ratanshi, Rosalind, Grosskurth, H., Woodruff Michael, Kaleebu, Pontiano, Cataldo Schietroma, Grant, P, Ernest M, Wright, E, Parkes-Ratanshi, R., Brecha Nicholas C., Van der Paal, L., Woodruff, Michael, Lieve Van der Paal, Kaleebu, P, Brecha, Nicholas C, Zampighi Guido A., Parkes-Ratanshi, R, Wright, Edward, Guido A Zampighi, Ernest M Wright, Susan Mugaba, Grosskurth Heiner, Van der Paal, Lieve, Parkes-Ratanshi Rosalind, Grosskurth, Heiner, Mugaba, Susan, Guido A. Zampighi, Kaleebu Pontiano, Mugaba, S., Wright, Ernest M, van der Paal, L, Van der Paal Lieve, Lorenzo M Zampighi, Edward Wright, Wright Ernest M., Mugaba Susan, Paul Grant, Pontiano Kaleebu, Lorenzo M. Zampighi, Kaleebu, P., Michael Woodruff, Mugaba, S, Zampighi, Lorenzo M, Grant, P., Heiner Grosskurth, Schietroma Cataldo, Rosalind Parkes-Ratanshi, Grosskurth, H, Nicholas C. Brecha, Wright, E., Grant, Paul, Zampighi, Guido A, Grant Paul, Nicholas C Brecha   +57 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source