Results 61 to 70 of about 305,999 (243)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Anisotropic AGN Outflows and Enrichment of the Intergalactic Medium
, 2009 We investigate the cosmological-scale influence of outflows driven by AGNs on metal enrichment of the intergalactic medium. AGNs are located in dense cosmological structures which tend to be anisotropic.
Barai +64 more
core +1 more source
Powerful Outflows and Feedback from Active Galactic Nuclei [PDF]
, 2015 Active Galactic Nuclei (AGN) represent the growth phases of the supermassive black holes in the center of almost every galaxy. Powerful, highly ionized winds, with velocities $\sim 0.1- 0.2c$ are a common feature in X--ray spectra of luminous AGN ...
A. King, K. Pounds
semanticscholar +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Production of the entire range of r-process nuclides by black hole accretion disc outflows from neutron star mergers [PDF]
, 2016 We consider $r$-process nucleosynthesis in outflows from black hole accretion discs formed in double neutron star and neutron star -- black hole mergers. These outflows, powered by angular momentum transport processes and nuclear recombination, represent
Meng-Ru Wu +3 more
semanticscholar +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Temperature Dependence of Solar Active Region Outflows
, 2010 Spectroscopic observations with the EUV Imaging Spectrometer (EIS) on Hinode have revealed large areas of high speed outflows at the periphery of many solar active regions.
Baker +20 more
core +1 more source
SMA observations of the proto brown dwarf candidate SSTB213 J041757 [PDF]
, 2014 Context. The previously identified source SSTB213 J041757 is a proto brown dwarf candidate in Taurus, which has two possible components A and B. It was found that component B is probably a class 0/I proto brown dwarf associated with an extended envelope.
C. -f. Lee +4 more
core +1 more source
Massive Outflows Associated with ATLASGAL Clumps [PDF]
, 2017 We have undertaken the largest survey for outflows within the Galactic plane using simultaneously observed and data. Out of a total of 919 ATLASGAL clumps, 325 have data suitable to identify outflows, and 225 (69% ± 3%) show high-velocity outflows.
A. Yang +3 more
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source