Results 61 to 70 of about 8,717 (264)

Quasar Massive Ionized Outflows Traced by CIV λ1549 and [OIII]λλ4959,5007

Frontiers in Astronomy and Space Sciences, 2017
The most luminous quasars (with bolometric luminosities are ≳ 1047 erg/s) show a high prevalence of CIV λ1549 and [OIII]λλ4959,5007 emission line profiles with strong blueshifts.
Paola Marziani, C. Alenka Negrete, Deborah Dultzin, Mary L. Martínez-Aldama, Ascensión Del Olmo, Mauro D'Onofrio, Giovanna M. Stirpe   +6 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Mass Loss in Be Stars: News from Two Fronts

Galaxies
Be stars are characterized by the presence of a circumstellar Keplerian disk formed from material ejected from the rapidly rotating stellar surface.
Alex C. Carciofi, Guilherme P. P. Bolzan, Pâmela R. Querido, Amanda C. Rubio, Jonathan Labadie-Bartz, Tajan H. de Amorim, Ariane C. Fonseca Silva, Vittória L. Schiavolim   +7 more
doaj   +1 more source

Magnetic Propeller Outflows

The Astrophysical Journal, 1999
A model is developed for magnetic `propeller'-driven outflows which cause a rapidly rotating magnetized star accreting from a disk to spin-down. Energy and angular momentum lost by the star goes into expelling most of the accreting disk matter.
Lovelace, R. V. E., Romanova, M. M., Bisnovatyi-Kogan, G. S.   +2 more
openaire   +2 more sources

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Observational Tests of Active Galactic Nuclei Feedback: An Overview of Approaches and Interpretation

Galaxies
Growing supermassive black holes (Active Galactic Nuclei; AGN) release energy with the potential to alter their host galaxies and larger-scale environment; a process named “AGN feedback”.
Chris M. Harrison, Cristina Ramos Almeida   +1 more
doaj   +1 more source

MODEL OF A DISK-OUTFLOW COUPLED SYSTEM: DISK-OUTFLOW SYMBIOSIS [PDF]

The Thirteenth Marcel Grossmann Meeting, 2015
Several observational evidences and deeper theoretical insights reveal that accretion and outflow/jet are strongly correlated. We model an advective disk-outflow coupled dynamics. We investigate the properties of the disk-outflow surface and how is it dependent on the spin of the black hole.
openaire   +2 more sources