Results 51 to 60 of about 8,717 (264)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A candidate proton cyclotron feature in the ultraluminous X-ray source NGC 4656 ULX-1

Astronomy & Astrophysics
Ultraluminous X-ray sources represent extreme super-Eddington accretion regimes, and a subset is now known to host highly magnetized neutron stars. However, direct observational probes of their surface magnetic fields remain scarce.
Cruz-Sanchez Nelson, Saavedra Enzo A., Fogantini Federico A., García Federico, Combi Jorge A., Bachetti Matteo, Imbrogno Matteo, Sidoli Lara, Marino Alessio   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mini-supernovae from white dwarf–neutron star mergers: Viewing-angle-dependent spectra and light curves

Astronomy & Astrophysics
Context. Unstable mass transfer may occur during white dwarf–neutron star (WD–NS) mergers, in which the WD can be tidally disrupted and form an accretion disk around the NS.
Kang Yacheng, Zhu Jin-Ping, Shao Lijing, Zhong Jiahang, Zhang Jinghao, Zhang Bing   +5 more
doaj   +1 more source

The Many Routes to AGN Feedback

Frontiers in Astronomy and Space Sciences, 2017
The energy released by Active Galactic Nuclei (AGN) in the form of radiation, winds, or radio plasma jets, is known to impact on the surrounding interstellar medium. The result of these processes, known as AGN (negative) feedback, is suggested to prevent
Raffaella Morganti, Raffaella Morganti
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Ages and zero age main sequence spin distribution of stars in detached eclipsing binaries

Astronomy & Astrophysics
Benchmarking fundamental stellar properties is essential for calibrating evolutionary models and establishing empirical relationships between mass, radius, luminosity, and related stellar properties.
Merle T., Van Rensbergen W., Siess L., De Greve J. P., Jansen K., Van Eck S., Van de Steene G.   +6 more
doaj   +1 more source

Hα emission from Mira (omicron Ceti) [PDF]

Serbian Astronomical Journal
Here we report spectral observations of Mira (omicron Ceti). The comparison between the spectra reveals Hα emission during three minima of the Mira cycle (August 2019, January 2024, and January 2025). The emission has equivalent width EW(Hα) ~ 4
Zamanov R.K., Irincheva V., Marchev V., Marchev D., Christova M.D.   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source