Results 51 to 60 of about 36,915 (264)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The –WIND RISK project: nowcast and simulation of thunderstorm outflows [PDF]

–WIND RISK is a research project dealing with measurement and modelling of wind fields within thunderstorm cumulonimbus clouds and outflows at the ground (i.e., downbursts and gust fronts). The general objective of the project is to advance the knowledge
Cassola F., Avolio E., Bechini R., Milelli M., Burlando M., Romanic D., De Martin F., Parodi A., Lagasio M., Miglietta M. M.   +9 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Complete Survey of Outflows in Perseus [PDF]

, 2010
We present a study on the impact of molecular outflows in the Perseus molecular cloud complex using the COMPLETE Survey large-scale \(^{12}CO(1-0)\) and \(^{13}CO(1-0)\) maps.
Goodman, Alyssa, Pineda, Jaime, Halle, Michael, Arce, Hector G., Borkin, Michelle, Borkin, Michelle A., Halle, Michael W., Pineda, Jaime E., Goodman, Alyssa A.   +8 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Does inflation reduce remittance outflows in Saudi Arabia?

, 2022
This study examines the potential relationship between inflation and remittance outflows in Saudi Arabia over the period 1971–2019 by applying the autoregressive distributed lag (ARDL) model.
Al-Abdulrazag, Bashier, Foudeh, Musa, Musa Foudeh, Bashier Al-Abdulrazag   +3 more
core   +1 more source

Cool outflows in galaxies and their implications [PDF]

, 2020
Neutral-atomic and molecular outflows are a common occurrence in galaxies, near and far. They operate over the full extent of their galaxy hosts, from the innermost regions of galactic nuclei to the outermost reaches of galaxy halos.
Veilleux, Sylvain,, Bolatto, Alberto D.,, Maiolino, Roberto,, Veilleux, Sylvain, Aalto, Susanne,, Maiolino, Roberto, Aalto, Susanne, Bolatto, Alberto D.   +7 more
core   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A candidate proton cyclotron feature in the ultraluminous X-ray source NGC 4656 ULX-1

Astronomy & Astrophysics
Ultraluminous X-ray sources represent extreme super-Eddington accretion regimes, and a subset is now known to host highly magnetized neutron stars. However, direct observational probes of their surface magnetic fields remain scarce.
Cruz-Sanchez Nelson, Saavedra Enzo A., Fogantini Federico A., García Federico, Combi Jorge A., Bachetti Matteo, Imbrogno Matteo, Sidoli Lara, Marino Alessio   +8 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source